Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia

Abstract Preeclampsia is a common disease of pregnancy that poses a serious threat to the safety of pregnant women and the fetus; however, the etiology of preeclampsia is inconclusive. Piwi-interacting RNAs (piRNAs) are novel non-coding RNAs that are present at high levels in germ cells and are asso...

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Autores principales:	Jie He, Miaomiao Chen, Jiacheng Xu, Jie Fang, Zheng Liu, Hongbo Qi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55ae9a1df42a42a193b7184d1cc71227
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spelling	oai:doaj.org-article:55ae9a1df42a42a193b7184d1cc712272021-12-02T18:49:28ZIdentification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia10.1038/s41598-021-95307-w2045-2322https://doaj.org/article/55ae9a1df42a42a193b7184d1cc712272021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95307-whttps://doaj.org/toc/2045-2322Abstract Preeclampsia is a common disease of pregnancy that poses a serious threat to the safety of pregnant women and the fetus; however, the etiology of preeclampsia is inconclusive. Piwi-interacting RNAs (piRNAs) are novel non-coding RNAs that are present at high levels in germ cells and are associated with spermatogenesis. Emerging evidence demonstrated that piRNA is expressed in a variety of human tissues and is closely associated with tumorigenesis. However, changes in the piRNA expression profile in the placenta have not been investigated. In this study, we used small RNA sequencing to evaluate the differences in piRNA expression profiles between preeclampsia and control patients and potential functions. Differential expression analysis found 41 up-regulated and 36 down-regulated piRNAs in preeclamptic samples. In addition, the functional enrichment analysis of piRNAs target genes indicated that they were related to the extracellular matrix (ECM) formation and tissue-specific. Finally, we examined the expression pattern of the PIWL family proteins in the placenta, and PIWL3 and PIWIL4 were the primary subtypes in the human placenta. In summary, this study first summarized the changes in the expression pattern of piRNA in preeclampsia and provided new clues for the regulatory role of piRNA in the human placenta.Jie HeMiaomiao ChenJiacheng XuJie FangZheng LiuHongbo QiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie He Miaomiao Chen Jiacheng Xu Jie Fang Zheng Liu Hongbo Qi Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia
description	Abstract Preeclampsia is a common disease of pregnancy that poses a serious threat to the safety of pregnant women and the fetus; however, the etiology of preeclampsia is inconclusive. Piwi-interacting RNAs (piRNAs) are novel non-coding RNAs that are present at high levels in germ cells and are associated with spermatogenesis. Emerging evidence demonstrated that piRNA is expressed in a variety of human tissues and is closely associated with tumorigenesis. However, changes in the piRNA expression profile in the placenta have not been investigated. In this study, we used small RNA sequencing to evaluate the differences in piRNA expression profiles between preeclampsia and control patients and potential functions. Differential expression analysis found 41 up-regulated and 36 down-regulated piRNAs in preeclamptic samples. In addition, the functional enrichment analysis of piRNAs target genes indicated that they were related to the extracellular matrix (ECM) formation and tissue-specific. Finally, we examined the expression pattern of the PIWL family proteins in the placenta, and PIWL3 and PIWIL4 were the primary subtypes in the human placenta. In summary, this study first summarized the changes in the expression pattern of piRNA in preeclampsia and provided new clues for the regulatory role of piRNA in the human placenta.
format	article
author	Jie He Miaomiao Chen Jiacheng Xu Jie Fang Zheng Liu Hongbo Qi
author_facet	Jie He Miaomiao Chen Jiacheng Xu Jie Fang Zheng Liu Hongbo Qi
author_sort	Jie He
title	Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia
title_short	Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia
title_full	Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia
title_fullStr	Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia
title_full_unstemmed	Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia
title_sort	identification and characterization of piwi-interacting rnas in human placentas of preeclampsia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55ae9a1df42a42a193b7184d1cc71227
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Identification and characterization of Piwi-interacting RNAs in human placentas of preeclampsia

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