Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence

Abstract Adolescence is a time of significant cortical changes in the ‘social brain’, a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated...

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Autores principales:	Sunhae Sul, Berna Güroğlu, Eveline A. Crone, Luke J. Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55af9212a2d743f6bdb0c0f7720eafa4
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spelling	oai:doaj.org-article:55af9212a2d743f6bdb0c0f7720eafa42021-12-02T16:08:11ZMedial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence10.1038/s41598-017-08692-62045-2322https://doaj.org/article/55af9212a2d743f6bdb0c0f7720eafa42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08692-6https://doaj.org/toc/2045-2322Abstract Adolescence is a time of significant cortical changes in the ‘social brain’, a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated how cortical development of the social brain relates to other-regarding behavior, in the context of fairness concerns. Participants aged between 9 to 23 years old responded to multiple rounds of ultimatum game proposals. The degree to which each participant considers fairness of intention (i.e., intention-based reciprocity) vs. outcome (i.e., egalitarianism) was quantified using economic utility models. We observed a gradual shift in other-regarding preferences from simple rule-based egalitarianism to complex intention-based reciprocity from early childhood to young adulthood. The preference shift was associated with cortical thinning of the dorsomedial prefrontal cortex and posterior temporal cortex. Meta-analytic reverse-inference analysis showed that these regions were involved in social inference. Importantly, the other-regarding preference shift was statistically mediated by cortical thinning in the dorsomedial prefrontal cortex. Together these findings suggest that development of the ability to perform sophisticated other-regarding social inference is associated with the structural changes of specific social brain regions in late adolescence.Sunhae SulBerna GüroğluEveline A. CroneLuke J. ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sunhae Sul Berna Güroğlu Eveline A. Crone Luke J. Chang Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
description	Abstract Adolescence is a time of significant cortical changes in the ‘social brain’, a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated how cortical development of the social brain relates to other-regarding behavior, in the context of fairness concerns. Participants aged between 9 to 23 years old responded to multiple rounds of ultimatum game proposals. The degree to which each participant considers fairness of intention (i.e., intention-based reciprocity) vs. outcome (i.e., egalitarianism) was quantified using economic utility models. We observed a gradual shift in other-regarding preferences from simple rule-based egalitarianism to complex intention-based reciprocity from early childhood to young adulthood. The preference shift was associated with cortical thinning of the dorsomedial prefrontal cortex and posterior temporal cortex. Meta-analytic reverse-inference analysis showed that these regions were involved in social inference. Importantly, the other-regarding preference shift was statistically mediated by cortical thinning in the dorsomedial prefrontal cortex. Together these findings suggest that development of the ability to perform sophisticated other-regarding social inference is associated with the structural changes of specific social brain regions in late adolescence.
format	article
author	Sunhae Sul Berna Güroğlu Eveline A. Crone Luke J. Chang
author_facet	Sunhae Sul Berna Güroğlu Eveline A. Crone Luke J. Chang
author_sort	Sunhae Sul
title	Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
title_short	Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
title_full	Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
title_fullStr	Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
title_full_unstemmed	Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
title_sort	medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/55af9212a2d743f6bdb0c0f7720eafa4
work_keys_str_mv	AT sunhaesul medialprefrontalcorticalthinningmediatesshiftsinotherregardingpreferencesduringadolescence AT bernaguroglu medialprefrontalcorticalthinningmediatesshiftsinotherregardingpreferencesduringadolescence AT evelineacrone medialprefrontalcorticalthinningmediatesshiftsinotherregardingpreferencesduringadolescence AT lukejchang medialprefrontalcorticalthinningmediatesshiftsinotherregardingpreferencesduringadolescence
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Medial prefrontal cortical thinning mediates shifts in other-regarding preferences during adolescence

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