Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Here the authors decode how core promoter elements regulate rate limiting steps of transcription using quantitative live imaging, genetics and modeling in early Drosophila embryos. TATA-driven promoters require one rate-limiting step while INR promoters need an extra step associated with Pol II paus...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Virginia L. Pimmett, Matthieu Dejean, Carola Fernandez, Antonio Trullo, Edouard Bertrand, Ovidiu Radulescu, Mounia Lagha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55b0451fd1cf4e94bb3a8c2e059b2a51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:55b0451fd1cf4e94bb3a8c2e059b2a51
record_format	dspace
spelling	oai:doaj.org-article:55b0451fd1cf4e94bb3a8c2e059b2a512021-12-02T16:26:32ZQuantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics10.1038/s41467-021-24461-62041-1723https://doaj.org/article/55b0451fd1cf4e94bb3a8c2e059b2a512021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24461-6https://doaj.org/toc/2041-1723Here the authors decode how core promoter elements regulate rate limiting steps of transcription using quantitative live imaging, genetics and modeling in early Drosophila embryos. TATA-driven promoters require one rate-limiting step while INR promoters need an extra step associated with Pol II pausing.Virginia L. PimmettMatthieu DejeanCarola FernandezAntonio TrulloEdouard BertrandOvidiu RadulescuMounia LaghaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Virginia L. Pimmett Matthieu Dejean Carola Fernandez Antonio Trullo Edouard Bertrand Ovidiu Radulescu Mounia Lagha Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
description	Here the authors decode how core promoter elements regulate rate limiting steps of transcription using quantitative live imaging, genetics and modeling in early Drosophila embryos. TATA-driven promoters require one rate-limiting step while INR promoters need an extra step associated with Pol II pausing.
format	article
author	Virginia L. Pimmett Matthieu Dejean Carola Fernandez Antonio Trullo Edouard Bertrand Ovidiu Radulescu Mounia Lagha
author_facet	Virginia L. Pimmett Matthieu Dejean Carola Fernandez Antonio Trullo Edouard Bertrand Ovidiu Radulescu Mounia Lagha
author_sort	Virginia L. Pimmett
title	Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
title_short	Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
title_full	Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
title_fullStr	Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
title_full_unstemmed	Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
title_sort	quantitative imaging of transcription in living drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55b0451fd1cf4e94bb3a8c2e059b2a51
work_keys_str_mv	AT virginialpimmett quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics AT matthieudejean quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics AT carolafernandez quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics AT antoniotrullo quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics AT edouardbertrand quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics AT ovidiuradulescu quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics AT mounialagha quantitativeimagingoftranscriptioninlivingdrosophilaembryosrevealstheimpactofcorepromotermotifsonpromoterstatedynamics
_version_	1718383991622467584

Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Ejemplares similares