Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations
Abstract Acetylcholinesterase, with a deep, narrow active-site gorge, attracts enormous interest due to its particularly high catalytic efficiency and its inhibitors used for treatment of Alzheimer’s disease. To facilitate the massive pass-through of the substrate and inhibitors, “breathing” motions...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/55b6ae60257f4292aada539feb55adcd |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|