Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy

Abstract Background Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been associated with increased mammographic density. Collagen fiber archite...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Clara Bodelon, Maeve Mullooly, Ruth M. Pfeiffer, Shaoqi Fan, Mustapha Abubakar, Petra Lenz, Pamela M. Vacek, Donald L. Weaver, Sally D. Herschorn, Jason M. Johnson, Brian L. Sprague, Stephen Hewitt, John Shepherd, Serghei Malkov, Patricia J. Keely, Kevin W. Eliceiri, Mark E. Sherman, Matthew W. Conklin, Gretchen L. Gierach
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Collagen fibers Mammographic density Breast pathology Second harmonic generation imaging Breast diseases Breast neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/55b709f4e4e248f1bf8d0e98540e2bf9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:55b709f4e4e248f1bf8d0e98540e2bf9
record_format	dspace
spelling	oai:doaj.org-article:55b709f4e4e248f1bf8d0e98540e2bf92021-11-14T12:11:54ZMammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy10.1186/s13058-021-01482-z1465-542Xhttps://doaj.org/article/55b709f4e4e248f1bf8d0e98540e2bf92021-11-01T00:00:00Zhttps://doi.org/10.1186/s13058-021-01482-zhttps://doaj.org/toc/1465-542XAbstract Background Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been associated with increased mammographic density. Collagen fiber architecture has been linked to poor outcomes in breast cancer. However, relationships of quantitative collagen fiber features assessed in diagnostic biopsies with mammographic density and lesion severity are not well-established. Methods Clinically indicated breast biopsies from 65 in situ or invasive breast cancer cases and 73 frequency matched-controls with a benign biopsy result were used to measure collagen fiber features (length, straightness, width, alignment, orientation and density (fibers/µm2)) using second harmonic generation microscopy in up to three regions of interest (ROIs) per biopsy: normal, benign breast disease, and cancer. Local and global mammographic density volumes were quantified in the ipsilateral breast in pre-biopsy full-field digital mammograms. Associations of fibrillar collagen features with mammographic density and severity of biopsy diagnosis were evaluated using generalized estimating equation models with an independent correlation structure to account for multiple ROIs within each biopsy section. Results Collagen fiber density was positively associated with the proportion of stroma on the biopsy slide (p < 0.001) and with local percent mammographic density volume at both the biopsy target (p = 0.035) and within a 2 mm perilesional ring (p = 0.02), but not with global mammographic density measures. As severity of the breast biopsy diagnosis increased at the ROI level, collagen fibers tended to be less dense, shorter, straighter, thinner, and more aligned with one another (p < 0.05). Conclusions Collagen fiber density was positively associated with local, but not global, mammographic density, suggesting that collagen microarchitecture may not translate into macroscopic mammographic features. However, collagen fiber features may be markers of cancer risk and/or progression among women referred for biopsy based on abnormal breast imaging.Clara BodelonMaeve MulloolyRuth M. PfeifferShaoqi FanMustapha AbubakarPetra LenzPamela M. VacekDonald L. WeaverSally D. HerschornJason M. JohnsonBrian L. SpragueStephen HewittJohn ShepherdSerghei MalkovPatricia J. KeelyKevin W. EliceiriMark E. ShermanMatthew W. ConklinGretchen L. GierachBMCarticleCollagen fibersMammographic densityBreast pathologySecond harmonic generation imagingBreast diseasesBreast neoplasmsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Collagen fibers Mammographic density Breast pathology Second harmonic generation imaging Breast diseases Breast neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Collagen fibers Mammographic density Breast pathology Second harmonic generation imaging Breast diseases Breast neoplasms Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Clara Bodelon Maeve Mullooly Ruth M. Pfeiffer Shaoqi Fan Mustapha Abubakar Petra Lenz Pamela M. Vacek Donald L. Weaver Sally D. Herschorn Jason M. Johnson Brian L. Sprague Stephen Hewitt John Shepherd Serghei Malkov Patricia J. Keely Kevin W. Eliceiri Mark E. Sherman Matthew W. Conklin Gretchen L. Gierach Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
description	Abstract Background Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been associated with increased mammographic density. Collagen fiber architecture has been linked to poor outcomes in breast cancer. However, relationships of quantitative collagen fiber features assessed in diagnostic biopsies with mammographic density and lesion severity are not well-established. Methods Clinically indicated breast biopsies from 65 in situ or invasive breast cancer cases and 73 frequency matched-controls with a benign biopsy result were used to measure collagen fiber features (length, straightness, width, alignment, orientation and density (fibers/µm2)) using second harmonic generation microscopy in up to three regions of interest (ROIs) per biopsy: normal, benign breast disease, and cancer. Local and global mammographic density volumes were quantified in the ipsilateral breast in pre-biopsy full-field digital mammograms. Associations of fibrillar collagen features with mammographic density and severity of biopsy diagnosis were evaluated using generalized estimating equation models with an independent correlation structure to account for multiple ROIs within each biopsy section. Results Collagen fiber density was positively associated with the proportion of stroma on the biopsy slide (p < 0.001) and with local percent mammographic density volume at both the biopsy target (p = 0.035) and within a 2 mm perilesional ring (p = 0.02), but not with global mammographic density measures. As severity of the breast biopsy diagnosis increased at the ROI level, collagen fibers tended to be less dense, shorter, straighter, thinner, and more aligned with one another (p < 0.05). Conclusions Collagen fiber density was positively associated with local, but not global, mammographic density, suggesting that collagen microarchitecture may not translate into macroscopic mammographic features. However, collagen fiber features may be markers of cancer risk and/or progression among women referred for biopsy based on abnormal breast imaging.
format	article
author	Clara Bodelon Maeve Mullooly Ruth M. Pfeiffer Shaoqi Fan Mustapha Abubakar Petra Lenz Pamela M. Vacek Donald L. Weaver Sally D. Herschorn Jason M. Johnson Brian L. Sprague Stephen Hewitt John Shepherd Serghei Malkov Patricia J. Keely Kevin W. Eliceiri Mark E. Sherman Matthew W. Conklin Gretchen L. Gierach
author_facet	Clara Bodelon Maeve Mullooly Ruth M. Pfeiffer Shaoqi Fan Mustapha Abubakar Petra Lenz Pamela M. Vacek Donald L. Weaver Sally D. Herschorn Jason M. Johnson Brian L. Sprague Stephen Hewitt John Shepherd Serghei Malkov Patricia J. Keely Kevin W. Eliceiri Mark E. Sherman Matthew W. Conklin Gretchen L. Gierach
author_sort	Clara Bodelon
title	Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
title_short	Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
title_full	Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
title_fullStr	Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
title_full_unstemmed	Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
title_sort	mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/55b709f4e4e248f1bf8d0e98540e2bf9
work_keys_str_mv	AT clarabodelon mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT maevemullooly mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT ruthmpfeiffer mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT shaoqifan mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT mustaphaabubakar mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT petralenz mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT pamelamvacek mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT donaldlweaver mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT sallydherschorn mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT jasonmjohnson mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT brianlsprague mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT stephenhewitt mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT johnshepherd mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT sergheimalkov mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT patriciajkeely mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT kevinweliceiri mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT markesherman mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT matthewwconklin mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy AT gretchenlgierach mammarycollagenarchitectureanditsassociationwithmammographicdensityandlesionseverityamongwomenundergoingimageguidedbreastbiopsy
_version_	1718429346230697984

Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy

Ejemplares similares