Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study

Abstract We analysed whole blood genome-wide expression data to identify gene co-expression modules shared by early traits of osteoporosis and atherosclerosis. Gene expression was profiled for the Young Finns Study participants. Bone mineral density and content were measured as early traits of osteo...

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Autores principales:	Binisha H. Mishra, Pashupati P. Mishra, Emma Raitoharju, Saara Marttila, Nina Mononen, Harri Sievänen, Jorma Viikari, Markus Juonala, Marika Laaksonen, Nina Hutri-Kähönen, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55ba293c76de490eb8878024557d1e77
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spelling	oai:doaj.org-article:55ba293c76de490eb8878024557d1e772021-12-02T13:26:58ZModular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study10.1038/s41598-021-86536-02045-2322https://doaj.org/article/55ba293c76de490eb8878024557d1e772021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86536-0https://doaj.org/toc/2045-2322Abstract We analysed whole blood genome-wide expression data to identify gene co-expression modules shared by early traits of osteoporosis and atherosclerosis. Gene expression was profiled for the Young Finns Study participants. Bone mineral density and content were measured as early traits of osteoporosis. Carotid and bulbus intima media thickness were measured as early traits of atherosclerosis. Joint association of the modules, identified with weighted co-expression analysis, with early traits of the diseases was tested with multivariate analysis. Among the six modules significantly correlated with early traits of both the diseases, two had significant (adjusted p-values (p.adj) < 0.05) and another two had suggestively significant (p.adj < 0.25) joint association with the two diseases after adjusting for age, sex, body mass index, smoking habit, alcohol consumption, and physical activity. The three most significant member genes from the significant modules were NOSIP, GXYLT2, and TRIM63 (p.adj ≤ 0.18). Genes in the modules were enriched with biological processes that have separately been found to be involved in either bone metabolism or atherosclerosis. The gene modules and their most significant member genes identified in this study support the osteoporosis-atherosclerosis comorbidity hypothesis and can provide new joint biomarkers for both diseases and their dual prevention.Binisha H. MishraPashupati P. MishraEmma RaitoharjuSaara MarttilaNina MononenHarri SievänenJorma ViikariMarkus JuonalaMarika LaaksonenNina Hutri-KähönenMika KähönenOlli T. RaitakariTerho LehtimäkiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Binisha H. Mishra Pashupati P. Mishra Emma Raitoharju Saara Marttila Nina Mononen Harri Sievänen Jorma Viikari Markus Juonala Marika Laaksonen Nina Hutri-Kähönen Mika Kähönen Olli T. Raitakari Terho Lehtimäki Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
description	Abstract We analysed whole blood genome-wide expression data to identify gene co-expression modules shared by early traits of osteoporosis and atherosclerosis. Gene expression was profiled for the Young Finns Study participants. Bone mineral density and content were measured as early traits of osteoporosis. Carotid and bulbus intima media thickness were measured as early traits of atherosclerosis. Joint association of the modules, identified with weighted co-expression analysis, with early traits of the diseases was tested with multivariate analysis. Among the six modules significantly correlated with early traits of both the diseases, two had significant (adjusted p-values (p.adj) < 0.05) and another two had suggestively significant (p.adj < 0.25) joint association with the two diseases after adjusting for age, sex, body mass index, smoking habit, alcohol consumption, and physical activity. The three most significant member genes from the significant modules were NOSIP, GXYLT2, and TRIM63 (p.adj ≤ 0.18). Genes in the modules were enriched with biological processes that have separately been found to be involved in either bone metabolism or atherosclerosis. The gene modules and their most significant member genes identified in this study support the osteoporosis-atherosclerosis comorbidity hypothesis and can provide new joint biomarkers for both diseases and their dual prevention.
format	article
author	Binisha H. Mishra Pashupati P. Mishra Emma Raitoharju Saara Marttila Nina Mononen Harri Sievänen Jorma Viikari Markus Juonala Marika Laaksonen Nina Hutri-Kähönen Mika Kähönen Olli T. Raitakari Terho Lehtimäki
author_facet	Binisha H. Mishra Pashupati P. Mishra Emma Raitoharju Saara Marttila Nina Mononen Harri Sievänen Jorma Viikari Markus Juonala Marika Laaksonen Nina Hutri-Kähönen Mika Kähönen Olli T. Raitakari Terho Lehtimäki
author_sort	Binisha H. Mishra
title	Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
title_short	Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
title_full	Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
title_fullStr	Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
title_full_unstemmed	Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
title_sort	modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the young finns study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55ba293c76de490eb8878024557d1e77
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Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study

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