‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)

Abstract Processing speed is an updated diagnostic factor for neurocognitive disorders (NCD) in DSM-5. This study investigated the characteristics of processing speed and their diagnostic values in NCD patients. A flanker test was conducted in 31 adults with NCD due to vascular disease (NCD-vascular...

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Autores principales:	Hanna Lu, Sandra S. M. Chan, Linda C. W. Lam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55ba98d3b3634518babbebead604a290
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spelling	oai:doaj.org-article:55ba98d3b3634518babbebead604a2902021-12-02T15:05:06Z‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)10.1038/s41598-017-00624-82045-2322https://doaj.org/article/55ba98d3b3634518babbebead604a2902017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00624-8https://doaj.org/toc/2045-2322Abstract Processing speed is an updated diagnostic factor for neurocognitive disorders (NCD) in DSM-5. This study investigated the characteristics of processing speed and their diagnostic values in NCD patients. A flanker test was conducted in 31 adults with NCD due to vascular disease (NCD-vascular), 36 patients with NCD due to Alzheimer’s disease (NCD-AD), and 137 healthy controls. The processing speed was evaluated using two measurements: mean reaction time (RT) and intra-individual variability of RT. Mean RT represents the global processing speed. Intra-individual variability of RT is the short-term fluctuation of RT and consists of two indices, which are intra-individual coefficient of variation of reaction time (ICV-RT) and intra-individual standard deviations (iSD). We observed elevated ICV-RT and iSD in NCD-AD and NCD-vascular patients. Additionally, there was a slowed RT in NCD-AD patients. The intra-individual variability of RT had a moderate power to differentiate NCD subgroups. The mean RT was able to discriminate the NCD-AD from NCD-vascular patients. Our findings highlight the clinical utility of the combined ‘two-level’ measurements of processing speed to distinguish between individuals with different cognitive status. Furthermore, the ‘two-level’ features of processing speed embedded in the psychometric property may also reflect the diverse aetiology underlying certain ‘disease-specific’ neurocognitive disorders.Hanna LuSandra S. M. ChanLinda C. W. LamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hanna Lu Sandra S. M. Chan Linda C. W. Lam ‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)
description	Abstract Processing speed is an updated diagnostic factor for neurocognitive disorders (NCD) in DSM-5. This study investigated the characteristics of processing speed and their diagnostic values in NCD patients. A flanker test was conducted in 31 adults with NCD due to vascular disease (NCD-vascular), 36 patients with NCD due to Alzheimer’s disease (NCD-AD), and 137 healthy controls. The processing speed was evaluated using two measurements: mean reaction time (RT) and intra-individual variability of RT. Mean RT represents the global processing speed. Intra-individual variability of RT is the short-term fluctuation of RT and consists of two indices, which are intra-individual coefficient of variation of reaction time (ICV-RT) and intra-individual standard deviations (iSD). We observed elevated ICV-RT and iSD in NCD-AD and NCD-vascular patients. Additionally, there was a slowed RT in NCD-AD patients. The intra-individual variability of RT had a moderate power to differentiate NCD subgroups. The mean RT was able to discriminate the NCD-AD from NCD-vascular patients. Our findings highlight the clinical utility of the combined ‘two-level’ measurements of processing speed to distinguish between individuals with different cognitive status. Furthermore, the ‘two-level’ features of processing speed embedded in the psychometric property may also reflect the diverse aetiology underlying certain ‘disease-specific’ neurocognitive disorders.
format	article
author	Hanna Lu Sandra S. M. Chan Linda C. W. Lam
author_facet	Hanna Lu Sandra S. M. Chan Linda C. W. Lam
author_sort	Hanna Lu
title	‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)
title_short	‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)
title_full	‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)
title_fullStr	‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)
title_full_unstemmed	‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)
title_sort	‘two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of dsm-5 mild neurocognitive disorders (ncd)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/55ba98d3b3634518babbebead604a290
work_keys_str_mv	AT hannalu twolevelmeasurementsofprocessingspeedascognitivemarkersinthedifferentialdiagnosisofdsm5mildneurocognitivedisordersncd AT sandrasmchan twolevelmeasurementsofprocessingspeedascognitivemarkersinthedifferentialdiagnosisofdsm5mildneurocognitivedisordersncd AT lindacwlam twolevelmeasurementsofprocessingspeedascognitivemarkersinthedifferentialdiagnosisofdsm5mildneurocognitivedisordersncd
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‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD)

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