Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer

Abstract Studies have consistently reported a significantly reduced incidence of ectopic pregnancy (EP) for frozen-thawed embryo transfer (ET) cycles compared with fresh cycles. However, only a few studies reported an association between endometrial preparation protocols on EP and results were confl...

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Autores principales:	Seung Chik Jwa, Masashi Takamura, Akira Kuwahara, Takeshi Kajihara, Osamu Ishihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55bce591dd5e45168742ef06b355c62a
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spelling	oai:doaj.org-article:55bce591dd5e45168742ef06b355c62a2021-12-02T16:38:48ZEffect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer10.1038/s41598-021-97044-62045-2322https://doaj.org/article/55bce591dd5e45168742ef06b355c62a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97044-6https://doaj.org/toc/2045-2322Abstract Studies have consistently reported a significantly reduced incidence of ectopic pregnancy (EP) for frozen-thawed embryo transfer (ET) cycles compared with fresh cycles. However, only a few studies reported an association between endometrial preparation protocols on EP and results were conflicting. A registry-based retrospective cohort study of 153,354 clinical pregnancies following frozen single ETs between 2014 and 2017 were conducted, of which 792 cases of EP (0.52%) were reported. Blastocyst embryo transfers accounted for 87% of the total sample and were significantly associated with a decreased risk for EP compared with early cleavage ET (0.90% vs. 0.46%, adjusted OR = 0.50, 95% CI, 0.41 to 0.60). Compared with natural cycles, hormone replacement cycles (HRC) demonstrated a similar risk for EP (0.53% vs. 0.47%, adjusted OR = 1.12, 95% CI, 0.89 to 1.42). Subgroup analysis with or without tubal factor infertility and early cleavage/blastocyst ETs demonstrated similar non-significant associations. Endometrial preparation protocols using clomiphene (CC) were associated with a significantly increased risk for EP (1.12%, adjusted OR = 2.34; 95% CI, 1.38 to 3.98). These findings suggest that HRC and natural cycles had a similar risk for EP. Endometrial preparation using CC was associated with an increased risk of EP in frozen embryo transfer cycles.Seung Chik JwaMasashi TakamuraAkira KuwaharaTakeshi KajiharaOsamu IshiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seung Chik Jwa Masashi Takamura Akira Kuwahara Takeshi Kajihara Osamu Ishihara Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
description	Abstract Studies have consistently reported a significantly reduced incidence of ectopic pregnancy (EP) for frozen-thawed embryo transfer (ET) cycles compared with fresh cycles. However, only a few studies reported an association between endometrial preparation protocols on EP and results were conflicting. A registry-based retrospective cohort study of 153,354 clinical pregnancies following frozen single ETs between 2014 and 2017 were conducted, of which 792 cases of EP (0.52%) were reported. Blastocyst embryo transfers accounted for 87% of the total sample and were significantly associated with a decreased risk for EP compared with early cleavage ET (0.90% vs. 0.46%, adjusted OR = 0.50, 95% CI, 0.41 to 0.60). Compared with natural cycles, hormone replacement cycles (HRC) demonstrated a similar risk for EP (0.53% vs. 0.47%, adjusted OR = 1.12, 95% CI, 0.89 to 1.42). Subgroup analysis with or without tubal factor infertility and early cleavage/blastocyst ETs demonstrated similar non-significant associations. Endometrial preparation protocols using clomiphene (CC) were associated with a significantly increased risk for EP (1.12%, adjusted OR = 2.34; 95% CI, 1.38 to 3.98). These findings suggest that HRC and natural cycles had a similar risk for EP. Endometrial preparation using CC was associated with an increased risk of EP in frozen embryo transfer cycles.
format	article
author	Seung Chik Jwa Masashi Takamura Akira Kuwahara Takeshi Kajihara Osamu Ishihara
author_facet	Seung Chik Jwa Masashi Takamura Akira Kuwahara Takeshi Kajihara Osamu Ishihara
author_sort	Seung Chik Jwa
title	Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
title_short	Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
title_full	Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
title_fullStr	Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
title_full_unstemmed	Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
title_sort	effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55bce591dd5e45168742ef06b355c62a
work_keys_str_mv	AT seungchikjwa effectofendometrialpreparationprotocolsontheriskofectopicpregnancyforfrozenembryotransfer AT masashitakamura effectofendometrialpreparationprotocolsontheriskofectopicpregnancyforfrozenembryotransfer AT akirakuwahara effectofendometrialpreparationprotocolsontheriskofectopicpregnancyforfrozenembryotransfer AT takeshikajihara effectofendometrialpreparationprotocolsontheriskofectopicpregnancyforfrozenembryotransfer AT osamuishihara effectofendometrialpreparationprotocolsontheriskofectopicpregnancyforfrozenembryotransfer
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Effect of endometrial preparation protocols on the risk of ectopic pregnancy for frozen embryo transfer

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