Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the dispositi...

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Autor principal:	John G. Jones
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	in vivo magnetic resonance liver metabolism hyperpolarization stable isotopes Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/55bdf0cd264b4ffcb6e042cf35ecc62f
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spelling	oai:doaj.org-article:55bdf0cd264b4ffcb6e042cf35ecc62f2021-11-25T18:20:39ZNon-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy10.3390/metabo111107512218-1989https://doaj.org/article/55bdf0cd264b4ffcb6e042cf35ecc62f2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/751https://doaj.org/toc/2218-1989The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.John G. JonesMDPI AGarticlein vivo magnetic resonanceliver metabolismhyperpolarizationstable isotopesMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 751, p 751 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	in vivo magnetic resonance liver metabolism hyperpolarization stable isotopes Microbiology QR1-502
spellingShingle	in vivo magnetic resonance liver metabolism hyperpolarization stable isotopes Microbiology QR1-502 John G. Jones Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
description	The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.
format	article
author	John G. Jones
author_facet	John G. Jones
author_sort	John G. Jones
title	Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
title_short	Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
title_full	Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
title_fullStr	Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
title_full_unstemmed	Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
title_sort	non-invasive analysis of human liver metabolism by magnetic resonance spectroscopy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55bdf0cd264b4ffcb6e042cf35ecc62f
work_keys_str_mv	AT johngjones noninvasiveanalysisofhumanlivermetabolismbymagneticresonancespectroscopy
_version_	1718411319890149376

Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

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