Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice

Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is im...

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Autores principales:	José Gabriel Barcia Durán, Tyler Lu, Sean Houghton, Fuqiang Geng, Ryan Schreiner, Jenny Xiang, Shahin Rafii, David Redmond, Raphaël Lis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/55bfd49a01c64b54879f2fc1d1c36b2b
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spelling	oai:doaj.org-article:55bfd49a01c64b54879f2fc1d1c36b2b2021-12-02T11:44:59ZEndothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice10.1038/s42003-021-01846-32399-3642https://doaj.org/article/55bfd49a01c64b54879f2fc1d1c36b2b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01846-3https://doaj.org/toc/2399-3642Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is important for maintaining long-term repopulating hematopoietic stem cells.José Gabriel Barcia DuránTyler LuSean HoughtonFuqiang GengRyan SchreinerJenny XiangShahin RafiiDavid RedmondRaphaël LisNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 José Gabriel Barcia Durán Tyler Lu Sean Houghton Fuqiang Geng Ryan Schreiner Jenny Xiang Shahin Rafii David Redmond Raphaël Lis Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
description	Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is important for maintaining long-term repopulating hematopoietic stem cells.
format	article
author	José Gabriel Barcia Durán Tyler Lu Sean Houghton Fuqiang Geng Ryan Schreiner Jenny Xiang Shahin Rafii David Redmond Raphaël Lis
author_facet	José Gabriel Barcia Durán Tyler Lu Sean Houghton Fuqiang Geng Ryan Schreiner Jenny Xiang Shahin Rafii David Redmond Raphaël Lis
author_sort	José Gabriel Barcia Durán
title	Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
title_short	Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
title_full	Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
title_fullStr	Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
title_full_unstemmed	Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
title_sort	endothelial jak3 expression enhances pro-hematopoietic angiocrine function in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55bfd49a01c64b54879f2fc1d1c36b2b
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Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice

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