Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice
Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is im...
Guardado en:
Autores principales: | José Gabriel Barcia Durán, Tyler Lu, Sean Houghton, Fuqiang Geng, Ryan Schreiner, Jenny Xiang, Shahin Rafii, David Redmond, Raphaël Lis |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/55bfd49a01c64b54879f2fc1d1c36b2b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors
por: Ignacio Benedicto, et al.
Publicado: (2017) -
Glutamine metabolism regulates endothelial to hematopoietic transition and hematopoietic lineage specification
por: Leal Oburoglu, et al.
Publicado: (2021) -
Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion.
por: David G Kent, et al.
Publicado: (2013) - JAK-STAT
-
Jak nas widzą…
por: Zuzanna Łopacińska‑Piędel
Publicado: (2021)