Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery

Bowl-shaped biodegradable polymersomes, or stomatocytes, have much potential as drug delivery systems, due to their intriguing properties, such as controllable size, programmable morphology, and versatile cargo encapsulation capability. In this contribution, we developed well-defined therapeutically...

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Autores principales:	Jingxin Shao, Shoupeng Cao, Hanglong Wu, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biodegradable stomatocytes aggregation-induced emission enzyme cross-linking autonomous motion intracellular delivery anticancer therapy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/55c0d2f42605435fbf7f420591de06ff
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spelling	oai:doaj.org-article:55c0d2f42605435fbf7f420591de06ff2021-11-25T18:41:01ZTherapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery10.3390/pharmaceutics131118331999-4923https://doaj.org/article/55c0d2f42605435fbf7f420591de06ff2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1833https://doaj.org/toc/1999-4923Bowl-shaped biodegradable polymersomes, or stomatocytes, have much potential as drug delivery systems, due to their intriguing properties, such as controllable size, programmable morphology, and versatile cargo encapsulation capability. In this contribution, we developed well-defined therapeutically active stomatocytes with aggregation-induced emission (AIE) features by self-assembly of biodegradable amphiphilic block copolymers, comprising poly(ethylene glycol) (PEG) and AIEgenic poly(trimethylene carbonate) (PTMC) moieties. The presence of the AIEgens endowed the as-prepared stomatocytes with intrinsic fluorescence, which was employed for imaging of cellular uptake of the particles. It simultaneously enabled the photo-mediated generation of reactive oxygen species (ROS) for photodynamic therapy. The potential of the therapeutic stomatocytes as cargo carriers was demonstrated by loading enzymes (catalase and glucose oxidase) in the nanocavity, followed by a cross-linking reaction to achieve stable encapsulation. This provided the particles with a robust motile function, which further strengthened their therapeutic effect. With these unique features, enzyme-loaded AIEgenic stomatocytes are an attractive platform to be exploited in the field of nanomedicine.Jingxin ShaoShoupeng CaoHanglong WuLoai K. E. A. AbdelmohsenJan C. M. van HestMDPI AGarticlebiodegradable stomatocytesaggregation-induced emissionenzyme cross-linkingautonomous motionintracellular deliveryanticancer therapyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1833, p 1833 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biodegradable stomatocytes aggregation-induced emission enzyme cross-linking autonomous motion intracellular delivery anticancer therapy Pharmacy and materia medica RS1-441
spellingShingle	biodegradable stomatocytes aggregation-induced emission enzyme cross-linking autonomous motion intracellular delivery anticancer therapy Pharmacy and materia medica RS1-441 Jingxin Shao Shoupeng Cao Hanglong Wu Loai K. E. A. Abdelmohsen Jan C. M. van Hest Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery
description	Bowl-shaped biodegradable polymersomes, or stomatocytes, have much potential as drug delivery systems, due to their intriguing properties, such as controllable size, programmable morphology, and versatile cargo encapsulation capability. In this contribution, we developed well-defined therapeutically active stomatocytes with aggregation-induced emission (AIE) features by self-assembly of biodegradable amphiphilic block copolymers, comprising poly(ethylene glycol) (PEG) and AIEgenic poly(trimethylene carbonate) (PTMC) moieties. The presence of the AIEgens endowed the as-prepared stomatocytes with intrinsic fluorescence, which was employed for imaging of cellular uptake of the particles. It simultaneously enabled the photo-mediated generation of reactive oxygen species (ROS) for photodynamic therapy. The potential of the therapeutic stomatocytes as cargo carriers was demonstrated by loading enzymes (catalase and glucose oxidase) in the nanocavity, followed by a cross-linking reaction to achieve stable encapsulation. This provided the particles with a robust motile function, which further strengthened their therapeutic effect. With these unique features, enzyme-loaded AIEgenic stomatocytes are an attractive platform to be exploited in the field of nanomedicine.
format	article
author	Jingxin Shao Shoupeng Cao Hanglong Wu Loai K. E. A. Abdelmohsen Jan C. M. van Hest
author_facet	Jingxin Shao Shoupeng Cao Hanglong Wu Loai K. E. A. Abdelmohsen Jan C. M. van Hest
author_sort	Jingxin Shao
title	Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery
title_short	Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery
title_full	Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery
title_fullStr	Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery
title_full_unstemmed	Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery
title_sort	therapeutic stomatocytes with aggregation induced emission for intracellular delivery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55c0d2f42605435fbf7f420591de06ff
work_keys_str_mv	AT jingxinshao therapeuticstomatocyteswithaggregationinducedemissionforintracellulardelivery AT shoupengcao therapeuticstomatocyteswithaggregationinducedemissionforintracellulardelivery AT hanglongwu therapeuticstomatocyteswithaggregationinducedemissionforintracellulardelivery AT loaikeaabdelmohsen therapeuticstomatocyteswithaggregationinducedemissionforintracellulardelivery AT jancmvanhest therapeuticstomatocyteswithaggregationinducedemissionforintracellulardelivery
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Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery

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