The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation
Di Liu,1,* Qihuan Li,1,2,* Jing Dong,3 Dong Li,4 Xizhu Xu,4 Weijia Xing,4 Xiaoyu Zhang,1 Weijie Cao,1 Haifeng Hou,4 Hao Wang,1,5 Manshu Song,1 Lixin Tao,1 Xiaoping Kang,6 Qun Meng,1 Wei Wang,1,4,5 Xiuhua Guo,1 Youxin Wang1 1Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Ca...
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oai:doaj.org-article:55c2a23ce2284924bc6abb39a91455982021-12-02T05:48:03ZThe Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation1178-7007https://doaj.org/article/55c2a23ce2284924bc6abb39a91455982019-11-01T00:00:00Zhttps://www.dovepress.com/the-association-between-normal-bmi-with-central-adiposity-and-proinfla-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Di Liu,1,* Qihuan Li,1,2,* Jing Dong,3 Dong Li,4 Xizhu Xu,4 Weijia Xing,4 Xiaoyu Zhang,1 Weijie Cao,1 Haifeng Hou,4 Hao Wang,1,5 Manshu Song,1 Lixin Tao,1 Xiaoping Kang,6 Qun Meng,1 Wei Wang,1,4,5 Xiuhua Guo,1 Youxin Wang1 1Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China; 2Meinian Institute of Health, Beijing 100191, People’s Republic of China; 3Center for Physical Examination, Xuanwu Hospital, Capital Medical University, Beijing 100050, People’s Republic of China; 4School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong Province, People’s Republic of China; 5School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia; 6The Rehabilitation Center, Beijing Xiaotangshan Hospital, Beijing 102211, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youxin WangSchool of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing 100069, People’s Republic of ChinaTel +86 10 83911779Email wangy@ccmu.edu.cn Xiuhua GuoSchool of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing 100069, People’s Republic of ChinaTel +86 10 83911504Email guoxiuh@ccmu.edu.cnBackground: The mechanism by which normal body mass index (BMI) with central adiposity (NWCA) increases the risk of the diseases has not been completely elucidated. The inflammatory role of immunoglobulin G (IgG) N-glycosylation in obesity defined by BMI or central adiposity defined by waist-to-hip ratio (WHR) was reported, respectively. We undertook this three-center cross-sectional study to determine the association between the IgG N-glycans and NWCA.Methods: The participants were categorized into four different phenotypes: normal BMI with normal WHR (NW), normal BMI with central adiposity (NWCA), obesity with normal WHR (ONCA) and obesity with central adiposity (OCA). The IgG N-glycans were analyzed using ultra-performance liquid chromatography analysis of released glycans, and differences among groups were compared.Results: In total, 17 out of 24 initial IgG N-glycans were significantly different among the four groups (NW, ONCA, NWCA and OCA) (P<0.05/6*78=0.0001). The changes of IgG glycans in central obesity (12 GPs) were more than those in obesity (3 GPs). In addition, lower galactosylation and bisecting GlcNAc and higher fucosylation were associated with increased risk of NWCA.Conclusion: Central obesity was involved in more changes of IgG N-glycosylation representing stronger inflammation than obesity, which might make a greater contribution to the risk of related disorders. NWCA was associated with an increased pro-inflammatory of IgG N-glycosylation, which was accompanied by the development of central obesity and other related disorders.Keywords: body mass index, BMI, waist-to-hip ratio, WHR, normal BMI with central adiposity, immunoglobulin G, N-glycosylation, N-glycanLiu DLi QDong JLi DXu XXing WZhang XCao WHou HWang HSong MTao LKang XMeng QWang WGuo XWang YDove Medical Pressarticlebody mass index (bmi)waist-to-hip ratio (whr)normal bmi with central adiposityimmunoglobulin gn-glycosylationn-glycanSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2373-2385 (2019) |
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body mass index (bmi) waist-to-hip ratio (whr) normal bmi with central adiposity immunoglobulin g n-glycosylation n-glycan Specialties of internal medicine RC581-951 |
| spellingShingle |
body mass index (bmi) waist-to-hip ratio (whr) normal bmi with central adiposity immunoglobulin g n-glycosylation n-glycan Specialties of internal medicine RC581-951 Liu D Li Q Dong J Li D Xu X Xing W Zhang X Cao W Hou H Wang H Song M Tao L Kang X Meng Q Wang W Guo X Wang Y The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation |
| description |
Di Liu,1,* Qihuan Li,1,2,* Jing Dong,3 Dong Li,4 Xizhu Xu,4 Weijia Xing,4 Xiaoyu Zhang,1 Weijie Cao,1 Haifeng Hou,4 Hao Wang,1,5 Manshu Song,1 Lixin Tao,1 Xiaoping Kang,6 Qun Meng,1 Wei Wang,1,4,5 Xiuhua Guo,1 Youxin Wang1 1Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China; 2Meinian Institute of Health, Beijing 100191, People’s Republic of China; 3Center for Physical Examination, Xuanwu Hospital, Capital Medical University, Beijing 100050, People’s Republic of China; 4School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong Province, People’s Republic of China; 5School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia; 6The Rehabilitation Center, Beijing Xiaotangshan Hospital, Beijing 102211, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youxin WangSchool of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing 100069, People’s Republic of ChinaTel +86 10 83911779Email wangy@ccmu.edu.cn
Xiuhua GuoSchool of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing 100069, People’s Republic of ChinaTel +86 10 83911504Email guoxiuh@ccmu.edu.cnBackground: The mechanism by which normal body mass index (BMI) with central adiposity (NWCA) increases the risk of the diseases has not been completely elucidated. The inflammatory role of immunoglobulin G (IgG) N-glycosylation in obesity defined by BMI or central adiposity defined by waist-to-hip ratio (WHR) was reported, respectively. We undertook this three-center cross-sectional study to determine the association between the IgG N-glycans and NWCA.Methods: The participants were categorized into four different phenotypes: normal BMI with normal WHR (NW), normal BMI with central adiposity (NWCA), obesity with normal WHR (ONCA) and obesity with central adiposity (OCA). The IgG N-glycans were analyzed using ultra-performance liquid chromatography analysis of released glycans, and differences among groups were compared.Results: In total, 17 out of 24 initial IgG N-glycans were significantly different among the four groups (NW, ONCA, NWCA and OCA) (P<0.05/6*78=0.0001). The changes of IgG glycans in central obesity (12 GPs) were more than those in obesity (3 GPs). In addition, lower galactosylation and bisecting GlcNAc and higher fucosylation were associated with increased risk of NWCA.Conclusion: Central obesity was involved in more changes of IgG N-glycosylation representing stronger inflammation than obesity, which might make a greater contribution to the risk of related disorders. NWCA was associated with an increased pro-inflammatory of IgG N-glycosylation, which was accompanied by the development of central obesity and other related disorders.Keywords: body mass index, BMI, waist-to-hip ratio, WHR, normal BMI with central adiposity, immunoglobulin G, N-glycosylation, N-glycan |
| format |
article |
| author |
Liu D Li Q Dong J Li D Xu X Xing W Zhang X Cao W Hou H Wang H Song M Tao L Kang X Meng Q Wang W Guo X Wang Y |
| author_facet |
Liu D Li Q Dong J Li D Xu X Xing W Zhang X Cao W Hou H Wang H Song M Tao L Kang X Meng Q Wang W Guo X Wang Y |
| author_sort |
Liu D |
| title |
The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation |
| title_short |
The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation |
| title_full |
The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation |
| title_fullStr |
The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation |
| title_full_unstemmed |
The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation |
| title_sort |
association between normal bmi with central adiposity and proinflammatory potential immunoglobulin g n-glycosylation |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/55c2a23ce2284924bc6abb39a9145598 |
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1718400229570510848 |