Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

Hongwei Lin,1,2 Qingchun Xie,1,2 Xin Huang,1,2 Junfeng Ban,1,2 Bo Wang,1,2 Xing Wei,3 Yanzhong Chen,1,2 Zhufen Lu1,2 1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Guangdong Provincial En...

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Autores principales:	Lin HW, Xie QC, Huang X, Ban JF, Wang B, Wei X, Chen YZ, Lu ZF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ultradeformable liposomes cationic imperatorin skin permeation transdermal drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/55c823c432cb4b4f84d6d9a2ff228284
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spelling	oai:doaj.org-article:55c823c432cb4b4f84d6d9a2ff2282842021-12-02T05:09:47ZIncreased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery1178-2013https://doaj.org/article/55c823c432cb4b4f84d6d9a2ff2282842018-02-01T00:00:00Zhttps://www.dovepress.com/increased-skin-permeation-efficiency-of-imperatorin-via-charged-ultrad-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hongwei Lin,1,2 Qingchun Xie,1,2 Xin Huang,1,2 Junfeng Ban,1,2 Bo Wang,1,2 Xing Wei,3 Yanzhong Chen,1,2 Zhufen Lu1,2 1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 3Guangdong Shennong Chinese Medicine Research Institute, Guangzhou, People’s Republic of China Aim: The aim of this work was to develop a novel vesicular carrier, ultradeformable liposomes (UDLs), to expand the applications of the Chinese herbal medicine, imperatorin (IMP), and increase its transdermal delivery. Methods: In this study, we prepared IMP-loaded UDLs using the thin-film hydration method and evaluated their encapsulation efficiency, vesicle deformability, skin permeation, and the amounts accumulated in different depths of the skin in vitro. The influence of different charged surfactants on the properties of the UDLs was also investigated. Results: The results showed that the UDLs containing cationic surfactants had high entrapment efficiency (60.32%±2.82%), an acceptable particle size (82.4±0.65 nm), high elasticity, and prolonged drug release. The penetration rate of IMP in cationic-UDLs was 3.45-fold greater than that of IMP suspension, which was the highest value among the vesicular carriers. UDLs modified with cationic surfactant also showed higher fluorescence intensity in deeper regions of the epidermis. Conclusion: The results of our study suggest that cationic surfactant-modified UDLs could increase the transdermal flux, prolong the release of the drug, and serve as an effective dermal delivery system for IMP. Keywords: ultradeformable liposomes, cationic, imperatorin, skin permeation, transdermal drug deliveryLin HWXie QCHuang XBan JFWang BWei XChen YZLu ZFDove Medical Pressarticleultradeformable liposomescationicimperatorinskin permeationtransdermal drug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 831-842 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultradeformable liposomes cationic imperatorin skin permeation transdermal drug delivery Medicine (General) R5-920
spellingShingle	ultradeformable liposomes cationic imperatorin skin permeation transdermal drug delivery Medicine (General) R5-920 Lin HW Xie QC Huang X Ban JF Wang B Wei X Chen YZ Lu ZF Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
description	Hongwei Lin,1,2 Qingchun Xie,1,2 Xin Huang,1,2 Junfeng Ban,1,2 Bo Wang,1,2 Xing Wei,3 Yanzhong Chen,1,2 Zhufen Lu1,2 1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 3Guangdong Shennong Chinese Medicine Research Institute, Guangzhou, People’s Republic of China Aim: The aim of this work was to develop a novel vesicular carrier, ultradeformable liposomes (UDLs), to expand the applications of the Chinese herbal medicine, imperatorin (IMP), and increase its transdermal delivery. Methods: In this study, we prepared IMP-loaded UDLs using the thin-film hydration method and evaluated their encapsulation efficiency, vesicle deformability, skin permeation, and the amounts accumulated in different depths of the skin in vitro. The influence of different charged surfactants on the properties of the UDLs was also investigated. Results: The results showed that the UDLs containing cationic surfactants had high entrapment efficiency (60.32%±2.82%), an acceptable particle size (82.4±0.65 nm), high elasticity, and prolonged drug release. The penetration rate of IMP in cationic-UDLs was 3.45-fold greater than that of IMP suspension, which was the highest value among the vesicular carriers. UDLs modified with cationic surfactant also showed higher fluorescence intensity in deeper regions of the epidermis. Conclusion: The results of our study suggest that cationic surfactant-modified UDLs could increase the transdermal flux, prolong the release of the drug, and serve as an effective dermal delivery system for IMP. Keywords: ultradeformable liposomes, cationic, imperatorin, skin permeation, transdermal drug delivery
format	article
author	Lin HW Xie QC Huang X Ban JF Wang B Wei X Chen YZ Lu ZF
author_facet	Lin HW Xie QC Huang X Ban JF Wang B Wei X Chen YZ Lu ZF
author_sort	Lin HW
title	Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
title_short	Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
title_full	Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
title_fullStr	Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
title_full_unstemmed	Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
title_sort	increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/55c823c432cb4b4f84d6d9a2ff228284
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Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery

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