The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders

Novel interest has arisen in recent years regarding bone, which is a very complex and dynamic tissue deputed to several functions ranging from mechanical and protective support to hematopoiesis and calcium homeostasis maintenance. In order to address these tasks, a very refined, continuous remodelin...

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Autores principales:	Federica Saponaro, Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Alessandro Saba, Clementina Manera, Grazia Chiellini
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endocannabinoids system (ECS) bone remodeling cannabinoid receptor type 2 (CB2R) osteoporosis bone cancer Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/55c89484d84a49b69cf984c79e30067e
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spelling	oai:doaj.org-article:55c89484d84a49b69cf984c79e30067e2021-11-25T17:55:53ZThe Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders10.3390/ijms2222123741422-00671661-6596https://doaj.org/article/55c89484d84a49b69cf984c79e30067e2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12374https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Novel interest has arisen in recent years regarding bone, which is a very complex and dynamic tissue deputed to several functions ranging from mechanical and protective support to hematopoiesis and calcium homeostasis maintenance. In order to address these tasks, a very refined, continuous remodeling process needs to occur involving the coordinated action of different types of bone cells: osteoblasts (OBs), which have the capacity to produce newly formed bone, and osteoclasts (OCs), which can remove old bone. Bone remodeling is a highly regulated process that requires many hormones and messenger molecules, both at the systemic and the local level. The whole picture is still not fully understood, and the role of novel actors, such as the components of the endocannabinoids system (ECS), including endogenous cannabinoid ligands (ECs), cannabinoid receptors (CBRs), and the enzymes responsible for endogenous ligand synthesis and breakdown, is extremely intriguing. This article reviews the connection between the ECS and skeletal health, supporting the potential use of cannabinoid receptor ligands for the treatment of bone diseases associated with accelerated osteoclastic bone resorption, including osteoporosis and bone metastasis.Federica SaponaroRebecca FerrisiFrancesca GadoBeatrice PoliniAlessandro SabaClementina ManeraGrazia ChielliniMDPI AGarticleendocannabinoids system (ECS)bone remodelingcannabinoid receptor type 2 (CB2R)osteoporosisbone cancerBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12374, p 12374 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endocannabinoids system (ECS) bone remodeling cannabinoid receptor type 2 (CB2R) osteoporosis bone cancer Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	endocannabinoids system (ECS) bone remodeling cannabinoid receptor type 2 (CB2R) osteoporosis bone cancer Biology (General) QH301-705.5 Chemistry QD1-999 Federica Saponaro Rebecca Ferrisi Francesca Gado Beatrice Polini Alessandro Saba Clementina Manera Grazia Chiellini The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
description	Novel interest has arisen in recent years regarding bone, which is a very complex and dynamic tissue deputed to several functions ranging from mechanical and protective support to hematopoiesis and calcium homeostasis maintenance. In order to address these tasks, a very refined, continuous remodeling process needs to occur involving the coordinated action of different types of bone cells: osteoblasts (OBs), which have the capacity to produce newly formed bone, and osteoclasts (OCs), which can remove old bone. Bone remodeling is a highly regulated process that requires many hormones and messenger molecules, both at the systemic and the local level. The whole picture is still not fully understood, and the role of novel actors, such as the components of the endocannabinoids system (ECS), including endogenous cannabinoid ligands (ECs), cannabinoid receptors (CBRs), and the enzymes responsible for endogenous ligand synthesis and breakdown, is extremely intriguing. This article reviews the connection between the ECS and skeletal health, supporting the potential use of cannabinoid receptor ligands for the treatment of bone diseases associated with accelerated osteoclastic bone resorption, including osteoporosis and bone metastasis.
format	article
author	Federica Saponaro Rebecca Ferrisi Francesca Gado Beatrice Polini Alessandro Saba Clementina Manera Grazia Chiellini
author_facet	Federica Saponaro Rebecca Ferrisi Francesca Gado Beatrice Polini Alessandro Saba Clementina Manera Grazia Chiellini
author_sort	Federica Saponaro
title	The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
title_short	The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
title_full	The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
title_fullStr	The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
title_full_unstemmed	The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders
title_sort	role of cannabinoids in bone metabolism: a new perspective for bone disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55c89484d84a49b69cf984c79e30067e
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The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders

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