Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability

It is not clear how circadian biochemical cascades are encoded into neural electrical signals. Here, using a combination of electrophysiology and modelling approaches in mice, the authors show activation of glycogen synthase kinase 3 modulates neural activity in the suprachiasmatic nuclei via regula...

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Autores principales:	Jodi R. Paul, Daniel DeWoskin, Laura J. McMeekin, Rita M. Cowell, Daniel B. Forger, Karen L. Gamble
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55cf1eed826d46158f2e65325000bb43
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spelling	oai:doaj.org-article:55cf1eed826d46158f2e65325000bb432021-12-02T16:56:46ZRegulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability10.1038/ncomms134702041-1723https://doaj.org/article/55cf1eed826d46158f2e65325000bb432016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13470https://doaj.org/toc/2041-1723It is not clear how circadian biochemical cascades are encoded into neural electrical signals. Here, using a combination of electrophysiology and modelling approaches in mice, the authors show activation of glycogen synthase kinase 3 modulates neural activity in the suprachiasmatic nuclei via regulation of the persistent sodium current, INaP.Jodi R. PaulDaniel DeWoskinLaura J. McMeekinRita M. CowellDaniel B. ForgerKaren L. GambleNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jodi R. Paul Daniel DeWoskin Laura J. McMeekin Rita M. Cowell Daniel B. Forger Karen L. Gamble Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
description	It is not clear how circadian biochemical cascades are encoded into neural electrical signals. Here, using a combination of electrophysiology and modelling approaches in mice, the authors show activation of glycogen synthase kinase 3 modulates neural activity in the suprachiasmatic nuclei via regulation of the persistent sodium current, INaP.
format	article
author	Jodi R. Paul Daniel DeWoskin Laura J. McMeekin Rita M. Cowell Daniel B. Forger Karen L. Gamble
author_facet	Jodi R. Paul Daniel DeWoskin Laura J. McMeekin Rita M. Cowell Daniel B. Forger Karen L. Gamble
author_sort	Jodi R. Paul
title	Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
title_short	Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
title_full	Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
title_fullStr	Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
title_full_unstemmed	Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
title_sort	regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/55cf1eed826d46158f2e65325000bb43
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Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability

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