Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines

Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines

Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluorom...

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Autores principales: Ferenc Béke, Ádám Mészáros, Ágnes Tóth, Bence Béla Botlik, Zoltán Novák
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/55d08cc60c9f43458b00a6acab6f6a5e
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spelling oai:doaj.org-article:55d08cc60c9f43458b00a6acab6f6a5e2021-12-02T10:48:19ZVicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines10.1038/s41467-020-19748-z2041-1723https://doaj.org/article/55d08cc60c9f43458b00a6acab6f6a5e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19748-zhttps://doaj.org/toc/2041-1723Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluoromethylated ethylene amines and diamines.Ferenc BékeÁdám MészárosÁgnes TóthBence Béla BotlikZoltán NovákNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ferenc Béke
Ádám Mészáros
Ágnes Tóth
Bence Béla Botlik
Zoltán Novák
Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
description Metal-free olefin diamination may display challenges, especially when targeting fluorinated amines. Here, the authors report a double nucleophilic functionalization of an activated alkene originated from a trifluoropropenyliodonium salt with two nucleophiles for the selective synthesis of trifluoromethylated ethylene amines and diamines.
format article
author Ferenc Béke
Ádám Mészáros
Ágnes Tóth
Bence Béla Botlik
Zoltán Novák
author_facet Ferenc Béke
Ádám Mészáros
Ágnes Tóth
Bence Béla Botlik
Zoltán Novák
author_sort Ferenc Béke
title Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_short Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_full Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_fullStr Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_full_unstemmed Vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
title_sort vicinal difunctionalization of carbon–carbon double bond for the platform synthesis of trifluoroalkyl amines
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/55d08cc60c9f43458b00a6acab6f6a5e
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AT adammeszaros vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
AT agnestoth vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
AT bencebelabotlik vicinaldifunctionalizationofcarboncarbondoublebondfortheplatformsynthesisoftrifluoroalkylamines
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