Diagnostic challenges in multiple system atrophy

Diana Obelieniene,1 Sandra Bauzaite,1 Ilona Kulakiene,2 Evaldas Keleras,2 Indre Eitmonaite,3 Daiva Rastenyte1 1Department of Neurology, 2Department of Radiology, 3Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Abstract: Multiple system atrophy is a progressive neurode...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Obelieniene D, Bauzaite S, Kulakiene I, Keleras E, Eitmonaite I, Rastenyte D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	multiple-system atrophy progressive aphasia dementia neurodegenerative diseases progressive supranuclear palsy. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/55d15670cb224156804222f1ddf65d8b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:55d15670cb224156804222f1ddf65d8b
record_format	dspace
spelling	oai:doaj.org-article:55d15670cb224156804222f1ddf65d8b2021-12-02T04:32:11ZDiagnostic challenges in multiple system atrophy1178-2021https://doaj.org/article/55d15670cb224156804222f1ddf65d8b2018-01-01T00:00:00Zhttps://www.dovepress.com/diagnostic-challenges-in-multiple-system-atrophy-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Diana Obelieniene,1 Sandra Bauzaite,1 Ilona Kulakiene,2 Evaldas Keleras,2 Indre Eitmonaite,3 Daiva Rastenyte1 1Department of Neurology, 2Department of Radiology, 3Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Abstract: Multiple system atrophy is a progressive neurodegenerative disorder that is characterized by autonomic failure, cerebellar ataxia and parkinsonism syndrome in various combinations. In spite of the presence of well-established clinical criteria for multiple system atrophy, ante-mortem diagnosis is difficult. In our case report, we present a 78-year-old female patient who presented with early progressive aphasia and severe autonomic dysfunction. Two years after appearance of the first symptoms, she fulfilled all the major criteria for probable multiple system atrophy with rapid progression. In addition, brain magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography findings were more typical for progressive supranuclear palsy. Clinically differentiating multiple system atrophy from progressive supranuclear palsy and other similar neurodegenerative disorders may be challenging in all stages of the disease, especially with atypical disease presentation. Keywords: multiple system atrophy, progressive aphasia, dementia, neurodegenerative diseases, progressive supranuclear palsy, FDG-PET, MRI, MRAObelieniene DBauzaite SKulakiene IKeleras EEitmonaite IRastenyte DDove Medical Pressarticlemultiple-system atrophyprogressive aphasiadementianeurodegenerative diseasesprogressive supranuclear palsy.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 179-184 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple-system atrophy progressive aphasia dementia neurodegenerative diseases progressive supranuclear palsy. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	multiple-system atrophy progressive aphasia dementia neurodegenerative diseases progressive supranuclear palsy. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Obelieniene D Bauzaite S Kulakiene I Keleras E Eitmonaite I Rastenyte D Diagnostic challenges in multiple system atrophy
description	Diana Obelieniene,1 Sandra Bauzaite,1 Ilona Kulakiene,2 Evaldas Keleras,2 Indre Eitmonaite,3 Daiva Rastenyte1 1Department of Neurology, 2Department of Radiology, 3Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Abstract: Multiple system atrophy is a progressive neurodegenerative disorder that is characterized by autonomic failure, cerebellar ataxia and parkinsonism syndrome in various combinations. In spite of the presence of well-established clinical criteria for multiple system atrophy, ante-mortem diagnosis is difficult. In our case report, we present a 78-year-old female patient who presented with early progressive aphasia and severe autonomic dysfunction. Two years after appearance of the first symptoms, she fulfilled all the major criteria for probable multiple system atrophy with rapid progression. In addition, brain magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography findings were more typical for progressive supranuclear palsy. Clinically differentiating multiple system atrophy from progressive supranuclear palsy and other similar neurodegenerative disorders may be challenging in all stages of the disease, especially with atypical disease presentation. Keywords: multiple system atrophy, progressive aphasia, dementia, neurodegenerative diseases, progressive supranuclear palsy, FDG-PET, MRI, MRA
format	article
author	Obelieniene D Bauzaite S Kulakiene I Keleras E Eitmonaite I Rastenyte D
author_facet	Obelieniene D Bauzaite S Kulakiene I Keleras E Eitmonaite I Rastenyte D
author_sort	Obelieniene D
title	Diagnostic challenges in multiple system atrophy
title_short	Diagnostic challenges in multiple system atrophy
title_full	Diagnostic challenges in multiple system atrophy
title_fullStr	Diagnostic challenges in multiple system atrophy
title_full_unstemmed	Diagnostic challenges in multiple system atrophy
title_sort	diagnostic challenges in multiple system atrophy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/55d15670cb224156804222f1ddf65d8b
work_keys_str_mv	AT obelieniened diagnosticchallengesinmultiplesystematrophy AT bauzaites diagnosticchallengesinmultiplesystematrophy AT kulakienei diagnosticchallengesinmultiplesystematrophy AT kelerase diagnosticchallengesinmultiplesystematrophy AT eitmonaitei diagnosticchallengesinmultiplesystematrophy AT rastenyted diagnosticchallengesinmultiplesystematrophy
_version_	1718401183967608832

Diagnostic challenges in multiple system atrophy

Ejemplares similares