Prenatal diagnosis of exomphalos and prediction of outcome

Abstract The aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, consid...

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Autores principales:	K. Nitzsche, G. Fitze, M. Rüdiger, P. Wimberger, C. Birdir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55d2f19530c84db0aab2bd9f3de3576c
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spelling	oai:doaj.org-article:55d2f19530c84db0aab2bd9f3de3576c2021-12-02T16:45:22ZPrenatal diagnosis of exomphalos and prediction of outcome10.1038/s41598-021-88245-02045-2322https://doaj.org/article/55d2f19530c84db0aab2bd9f3de3576c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88245-0https://doaj.org/toc/2045-2322Abstract The aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, considering the measurement of ratios. The 41 fetuses with exomphalos were examined, 34 cases (82.9%) with karyotyping and 16 cases (39%) with an abnormal karyotype. Outcome of 39 cases showed 6 abortions (15.4%), 15 terminations (38.5%), an intrauterine fetal death (2.5%) and 17 alive babies (43.6%), which were grouped in two: small exomphalos (n = 6, 35.3%) and big exomphalos (n = 11, 64.7%). Maximal diameter of exomphalos/abdomen circumference-ratio (EDmax/AC-ratio) with a cut-off of 0.24 showed a better predictive value of postnatal primary closure. Exomphalos is correlated with abnormal karyotype. EDmax/AC-ratio gives the best prediction for postnatal primary closure of the defect.K. NitzscheG. FitzeM. RüdigerP. WimbergerC. BirdirNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K. Nitzsche G. Fitze M. Rüdiger P. Wimberger C. Birdir Prenatal diagnosis of exomphalos and prediction of outcome
description	Abstract The aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, considering the measurement of ratios. The 41 fetuses with exomphalos were examined, 34 cases (82.9%) with karyotyping and 16 cases (39%) with an abnormal karyotype. Outcome of 39 cases showed 6 abortions (15.4%), 15 terminations (38.5%), an intrauterine fetal death (2.5%) and 17 alive babies (43.6%), which were grouped in two: small exomphalos (n = 6, 35.3%) and big exomphalos (n = 11, 64.7%). Maximal diameter of exomphalos/abdomen circumference-ratio (EDmax/AC-ratio) with a cut-off of 0.24 showed a better predictive value of postnatal primary closure. Exomphalos is correlated with abnormal karyotype. EDmax/AC-ratio gives the best prediction for postnatal primary closure of the defect.
format	article
author	K. Nitzsche G. Fitze M. Rüdiger P. Wimberger C. Birdir
author_facet	K. Nitzsche G. Fitze M. Rüdiger P. Wimberger C. Birdir
author_sort	K. Nitzsche
title	Prenatal diagnosis of exomphalos and prediction of outcome
title_short	Prenatal diagnosis of exomphalos and prediction of outcome
title_full	Prenatal diagnosis of exomphalos and prediction of outcome
title_fullStr	Prenatal diagnosis of exomphalos and prediction of outcome
title_full_unstemmed	Prenatal diagnosis of exomphalos and prediction of outcome
title_sort	prenatal diagnosis of exomphalos and prediction of outcome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55d2f19530c84db0aab2bd9f3de3576c
work_keys_str_mv	AT knitzsche prenataldiagnosisofexomphalosandpredictionofoutcome AT gfitze prenataldiagnosisofexomphalosandpredictionofoutcome AT mrudiger prenataldiagnosisofexomphalosandpredictionofoutcome AT pwimberger prenataldiagnosisofexomphalosandpredictionofoutcome AT cbirdir prenataldiagnosisofexomphalosandpredictionofoutcome
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Prenatal diagnosis of exomphalos and prediction of outcome

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