Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART

Abstract Objectives Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general population. Here we assess CMV and inflammatory markers linked with vascu...

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Autores principales:	Ika Prasetya Wijaya, Birry Karim, Mohamad Syahrir Azizi, Ibnu Ariyanto, Arif Mansjoer, Evy Yunihastuti, Kuntjoro Harimurti, Idrus Alwi, Silvia Lee, Patricia Price
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	CMV Endothelial function HIV Inflammatory biomarkers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/55d32b0dd0054ddf94dc9ce257d20a67
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spelling	oai:doaj.org-article:55d32b0dd0054ddf94dc9ce257d20a672021-11-14T12:08:14ZCytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART10.1186/s12981-021-00410-71742-6405https://doaj.org/article/55d32b0dd0054ddf94dc9ce257d20a672021-11-01T00:00:00Zhttps://doi.org/10.1186/s12981-021-00410-7https://doaj.org/toc/1742-6405Abstract Objectives Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general population. Here we assess CMV and inflammatory markers linked with vascular health in young adult patients treated in Indonesia. Study design HIV-infected adults (n = 32) were examined when they began antiretroviral therapy (ART) with < 200 CD4 T-cells/µl (V0) and after 60 months (V60). Age-matched healthy controls (HC, n = 32) were assessed once. Methods Flow Mediated Dilatation (FMD) was assessed by ultrasound on brachial arteries at V60 and in HC. Plasma markers of immune activation and endothelial activation, and CMV antibodies (lysate, gB, IE-1) were assessed in all samples. Results were assessed using bivariate (non-parametric) and multivariable analyses. Results Levels of inflammatory biomarkers and CMV antibodies declined on ART, but the antibodies remained higher than in HC. FMD values were similar in patients and HC at V60. In HIV patients, levels of CMV lysate antibody correlated inversely (r = − 0.37) with FMD. The optimal model predicting lower FMD values (adjusted R2 = 0.214, p = 0.012) included CMV lysate antibodies and chondroitin sulphate. In HC, levels of sTNFR correlated inversely with FMD (r = − 0.41) and remained as a risk factor in the optimal multivariable model, with CMV glycoprotein-B (gB) antibody predicting a healthier FMD (adjusted R2 = 0.248, p = 0.013). Conclusions Higher levels CMV antibodies optimally predict vascular health measured by FMD in HIV patients. However in healthy controls, sTNFR marks risk and CMV gB antibody may be protective.Ika Prasetya WijayaBirry KarimMohamad Syahrir AziziIbnu AriyantoArif MansjoerEvy YunihastutiKuntjoro HarimurtiIdrus AlwiSilvia LeePatricia PriceBMCarticleCMVEndothelial functionHIVInflammatory biomarkersImmunologic diseases. AllergyRC581-607ENAIDS Research and Therapy, Vol 18, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CMV Endothelial function HIV Inflammatory biomarkers Immunologic diseases. Allergy RC581-607
spellingShingle	CMV Endothelial function HIV Inflammatory biomarkers Immunologic diseases. Allergy RC581-607 Ika Prasetya Wijaya Birry Karim Mohamad Syahrir Azizi Ibnu Ariyanto Arif Mansjoer Evy Yunihastuti Kuntjoro Harimurti Idrus Alwi Silvia Lee Patricia Price Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART
description	Abstract Objectives Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general population. Here we assess CMV and inflammatory markers linked with vascular health in young adult patients treated in Indonesia. Study design HIV-infected adults (n = 32) were examined when they began antiretroviral therapy (ART) with < 200 CD4 T-cells/µl (V0) and after 60 months (V60). Age-matched healthy controls (HC, n = 32) were assessed once. Methods Flow Mediated Dilatation (FMD) was assessed by ultrasound on brachial arteries at V60 and in HC. Plasma markers of immune activation and endothelial activation, and CMV antibodies (lysate, gB, IE-1) were assessed in all samples. Results were assessed using bivariate (non-parametric) and multivariable analyses. Results Levels of inflammatory biomarkers and CMV antibodies declined on ART, but the antibodies remained higher than in HC. FMD values were similar in patients and HC at V60. In HIV patients, levels of CMV lysate antibody correlated inversely (r = − 0.37) with FMD. The optimal model predicting lower FMD values (adjusted R2 = 0.214, p = 0.012) included CMV lysate antibodies and chondroitin sulphate. In HC, levels of sTNFR correlated inversely with FMD (r = − 0.41) and remained as a risk factor in the optimal multivariable model, with CMV glycoprotein-B (gB) antibody predicting a healthier FMD (adjusted R2 = 0.248, p = 0.013). Conclusions Higher levels CMV antibodies optimally predict vascular health measured by FMD in HIV patients. However in healthy controls, sTNFR marks risk and CMV gB antibody may be protective.
format	article
author	Ika Prasetya Wijaya Birry Karim Mohamad Syahrir Azizi Ibnu Ariyanto Arif Mansjoer Evy Yunihastuti Kuntjoro Harimurti Idrus Alwi Silvia Lee Patricia Price
author_facet	Ika Prasetya Wijaya Birry Karim Mohamad Syahrir Azizi Ibnu Ariyanto Arif Mansjoer Evy Yunihastuti Kuntjoro Harimurti Idrus Alwi Silvia Lee Patricia Price
author_sort	Ika Prasetya Wijaya
title	Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART
title_short	Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART
title_full	Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART
title_fullStr	Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART
title_full_unstemmed	Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART
title_sort	cytomegalovirus may influence vascular endothelial health in indonesian hiv-infected patients after 5 years on art
publisher	BMC
publishDate	2021
url	https://doaj.org/article/55d32b0dd0054ddf94dc9ce257d20a67
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Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART

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