Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma

Altaf A Kondkar, Tahira Sultan, Faisal A Almobarak, Hatem Kalantan, Saleh A Al-Obeidan, Khaled K Abu-Amero Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia Purpose: Retinal ganglion cell (RGC) death is a key feature of glaucoma....

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Autores principales:	Kondkar AA, Sultan T, Almobarak FA, Kalantan H, Al-Obeidan SA, Abu-Amero KK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	glaucoma inflammation oxidative stress POAG TNF-α Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/55d603a719f14e7e87546687ad7a3f1d
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spelling	oai:doaj.org-article:55d603a719f14e7e87546687ad7a3f1d2021-12-02T04:03:30ZAssociation of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma1177-5483https://doaj.org/article/55d603a719f14e7e87546687ad7a3f1d2018-04-01T00:00:00Zhttps://www.dovepress.com/association-of-increased-levels-of-plasma-tumor-necrosis-factor-alpha--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Altaf A Kondkar, Tahira Sultan, Faisal A Almobarak, Hatem Kalantan, Saleh A Al-Obeidan, Khaled K Abu-Amero Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia Purpose: Retinal ganglion cell (RGC) death is a key feature of glaucoma. Elevated levels of tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, can induce RGC apoptosis and play a critical role in glaucomatous neurodegeneration. Based on the possible role of inflammation and oxidative stress in the pathogenesis of primary open-angle glaucoma (POAG), we investigated the association between plasma levels of TNF-α and POAG or its clinical indices in comparison to non-glaucomatous controls. Patients and methods: In a case–control retrospective cohort of 51 POAG cases and 88 controls, plasma TNF-α levels were measured using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on an automated ELISA analyzer. Results: Mean TNF-α level was significantly elevated in POAG cases (1.88 ± 2.17 pg/mL) than the controls (0.93 ± 1.49 pg/mL; p = 0.003). The overall dose–response trend was significant (Χ2 = 6.12, df = 2; p = 0.047). No statistical difference was seen in age, gender and systemic disease distribution. A modest negative and significant correlation was seen between TNF-α level and number of antiglaucoma medications, an important clinical index of POAG severity. Moreover, logistic regression analysis showed that the risk of POAG was most significantly affected by TNF-α level and not by age and sex. Conclusion: High systemic level of an inflammatory cytokine, TNF-α, is associated with POAG; however, its possible use as a biomarker for early glaucoma diagnosis and/or disease severity needs further investigation. Keywords: apoptosis, biomarker, cytokines, ELISA, inflammation, neurodegeneration, oxidative stressKondkar AASultan TAlmobarak FAKalantan HAl-Obeidan SAAbu-Amero KKDove Medical Pressarticleglaucomainflammationoxidative stressPOAGTNF-αOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 701-706 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma inflammation oxidative stress POAG TNF-α Ophthalmology RE1-994
spellingShingle	glaucoma inflammation oxidative stress POAG TNF-α Ophthalmology RE1-994 Kondkar AA Sultan T Almobarak FA Kalantan H Al-Obeidan SA Abu-Amero KK Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
description	Altaf A Kondkar, Tahira Sultan, Faisal A Almobarak, Hatem Kalantan, Saleh A Al-Obeidan, Khaled K Abu-Amero Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia Purpose: Retinal ganglion cell (RGC) death is a key feature of glaucoma. Elevated levels of tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, can induce RGC apoptosis and play a critical role in glaucomatous neurodegeneration. Based on the possible role of inflammation and oxidative stress in the pathogenesis of primary open-angle glaucoma (POAG), we investigated the association between plasma levels of TNF-α and POAG or its clinical indices in comparison to non-glaucomatous controls. Patients and methods: In a case–control retrospective cohort of 51 POAG cases and 88 controls, plasma TNF-α levels were measured using an enzyme-linked immunosorbent assay (ELISA). The assay was performed in duplicates on an automated ELISA analyzer. Results: Mean TNF-α level was significantly elevated in POAG cases (1.88 ± 2.17 pg/mL) than the controls (0.93 ± 1.49 pg/mL; p = 0.003). The overall dose–response trend was significant (Χ2 = 6.12, df = 2; p = 0.047). No statistical difference was seen in age, gender and systemic disease distribution. A modest negative and significant correlation was seen between TNF-α level and number of antiglaucoma medications, an important clinical index of POAG severity. Moreover, logistic regression analysis showed that the risk of POAG was most significantly affected by TNF-α level and not by age and sex. Conclusion: High systemic level of an inflammatory cytokine, TNF-α, is associated with POAG; however, its possible use as a biomarker for early glaucoma diagnosis and/or disease severity needs further investigation. Keywords: apoptosis, biomarker, cytokines, ELISA, inflammation, neurodegeneration, oxidative stress
format	article
author	Kondkar AA Sultan T Almobarak FA Kalantan H Al-Obeidan SA Abu-Amero KK
author_facet	Kondkar AA Sultan T Almobarak FA Kalantan H Al-Obeidan SA Abu-Amero KK
author_sort	Kondkar AA
title	Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
title_short	Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
title_full	Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
title_fullStr	Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
title_full_unstemmed	Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
title_sort	association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/55d603a719f14e7e87546687ad7a3f1d
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_version_	1718401430816030720

Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma

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