Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular fu...

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Autores principales:	Stéphanie Rimbaud, Matthieu Ruiz, Jérôme Piquereau, Philippe Mateo, Dominique Fortin, Vladimir Veksler, Anne Garnier, Renée Ventura-Clapier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55d71f1aa94a44e58ee99fbbcae90486
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spelling	oai:doaj.org-article:55d71f1aa94a44e58ee99fbbcae904862021-11-18T07:36:16ZResveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.1932-620310.1371/journal.pone.0026391https://doaj.org/article/55d71f1aa94a44e58ee99fbbcae904862011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22028869/?tool=EBIhttps://doaj.org/toc/1932-6203Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p<0.001), and prevented the 25% reduction in body weight in HS-NT (P<0.001). Moreover, RSV counteracted the development of cardiac dysfunction (fractional shortening -34% in HS-NT) as evaluated by echocardiography, which occurred without regression of hypertension or hypertrophy. Moreover, aortic endothelial dysfunction present in HS-NT was prevented in resveratrol-treated rats. Resveratrol treatment tended to preserve mitochondrial mass and biogenesis and completely protected mitochondrial fatty acid oxidation and PPARα (peroxisome proliferator-activated receptor α) expression. We conclude that resveratrol treatment exerts beneficial protective effects on survival, endothelium-dependent smooth muscle relaxation and cardiac contractile and mitochondrial function, suggesting that resveratrol or metabolic activators could be a relevant therapy in hypertension-induced HF.Stéphanie RimbaudMatthieu RuizJérôme PiquereauPhilippe MateoDominique FortinVladimir VekslerAnne GarnierRenée Ventura-ClapierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26391 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stéphanie Rimbaud Matthieu Ruiz Jérôme Piquereau Philippe Mateo Dominique Fortin Vladimir Veksler Anne Garnier Renée Ventura-Clapier Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
description	Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic therapy of HF. Survival, ventricular and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive model of HF, the Dahl salt-sensitive rat fed with a high-salt diet (HS-NT). Resveratrol (18 mg/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which occurred 3 weeks after salt addition). Resveratrol treatment improved survival (64% in HS-RSV versus 15% in HS-NT, p<0.001), and prevented the 25% reduction in body weight in HS-NT (P<0.001). Moreover, RSV counteracted the development of cardiac dysfunction (fractional shortening -34% in HS-NT) as evaluated by echocardiography, which occurred without regression of hypertension or hypertrophy. Moreover, aortic endothelial dysfunction present in HS-NT was prevented in resveratrol-treated rats. Resveratrol treatment tended to preserve mitochondrial mass and biogenesis and completely protected mitochondrial fatty acid oxidation and PPARα (peroxisome proliferator-activated receptor α) expression. We conclude that resveratrol treatment exerts beneficial protective effects on survival, endothelium-dependent smooth muscle relaxation and cardiac contractile and mitochondrial function, suggesting that resveratrol or metabolic activators could be a relevant therapy in hypertension-induced HF.
format	article
author	Stéphanie Rimbaud Matthieu Ruiz Jérôme Piquereau Philippe Mateo Dominique Fortin Vladimir Veksler Anne Garnier Renée Ventura-Clapier
author_facet	Stéphanie Rimbaud Matthieu Ruiz Jérôme Piquereau Philippe Mateo Dominique Fortin Vladimir Veksler Anne Garnier Renée Ventura-Clapier
author_sort	Stéphanie Rimbaud
title	Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
title_short	Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
title_full	Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
title_fullStr	Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
title_full_unstemmed	Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
title_sort	resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/55d71f1aa94a44e58ee99fbbcae90486
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Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

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