Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis

Abstract Acute pancreatitis (AP) results in potentially harmful blood glucose fluctuations, affecting patient prognosis. This study aimed to explore the relationship between blood glucose-related indicators and in-hospital mortality in critically ill patients with AP. We extracted data on AP patient...

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Autores principales:	Yan Lu, Qiaohong Zhang, Jianjie Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55db22a305c6496f9b968f3910de8bf9
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spelling	oai:doaj.org-article:55db22a305c6496f9b968f3910de8bf92021-12-02T18:47:04ZBlood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis10.1038/s41598-021-94697-12045-2322https://doaj.org/article/55db22a305c6496f9b968f3910de8bf92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94697-1https://doaj.org/toc/2045-2322Abstract Acute pancreatitis (AP) results in potentially harmful blood glucose fluctuations, affecting patient prognosis. This study aimed to explore the relationship between blood glucose-related indicators and in-hospital mortality in critically ill patients with AP. We extracted data on AP patients from the Multiparameter Intelligent Monitoring in Intensive Care III database. Initial glucose (Glucose_initial), maximum glucose (Glucose_max), minimum glucose (Glucose_min), mean glucose (Glucose_mean), and glucose variability (glucose standard deviation [Glucose_SD] and glucose coefficient of variation [Glucose_CV]) were selected as blood glucose-related indicators. Logistic regression models and the Lowess smoothing curves were used to display the association between significant blood glucose-related indicators and in-hospital mortality. Survivors and non-survivors showed significant differences in Glucose_max, Glucose_mean, Glucose_SD, and Glucose_CV (P < 0.05). Glucose_max, Glucose_mean, Glucose_SD, and Glucose_CV were risk factors for in-hospital mortality in AP patients (OR > 1; P < 0.05). According to the Lowess smoothing curve, the overall trends of blood glucose-related indicators showed a non-linear correlation with in-hospital mortality. Glucose_max, Glucose_mean, Glucose_SD, and Glucose_CV were associated with in-hospital mortality in critically ill patients with AP.Yan LuQiaohong ZhangJianjie LouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Lu Qiaohong Zhang Jianjie Lou Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
description	Abstract Acute pancreatitis (AP) results in potentially harmful blood glucose fluctuations, affecting patient prognosis. This study aimed to explore the relationship between blood glucose-related indicators and in-hospital mortality in critically ill patients with AP. We extracted data on AP patients from the Multiparameter Intelligent Monitoring in Intensive Care III database. Initial glucose (Glucose_initial), maximum glucose (Glucose_max), minimum glucose (Glucose_min), mean glucose (Glucose_mean), and glucose variability (glucose standard deviation [Glucose_SD] and glucose coefficient of variation [Glucose_CV]) were selected as blood glucose-related indicators. Logistic regression models and the Lowess smoothing curves were used to display the association between significant blood glucose-related indicators and in-hospital mortality. Survivors and non-survivors showed significant differences in Glucose_max, Glucose_mean, Glucose_SD, and Glucose_CV (P < 0.05). Glucose_max, Glucose_mean, Glucose_SD, and Glucose_CV were risk factors for in-hospital mortality in AP patients (OR > 1; P < 0.05). According to the Lowess smoothing curve, the overall trends of blood glucose-related indicators showed a non-linear correlation with in-hospital mortality. Glucose_max, Glucose_mean, Glucose_SD, and Glucose_CV were associated with in-hospital mortality in critically ill patients with AP.
format	article
author	Yan Lu Qiaohong Zhang Jianjie Lou
author_facet	Yan Lu Qiaohong Zhang Jianjie Lou
author_sort	Yan Lu
title	Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
title_short	Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
title_full	Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
title_fullStr	Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
title_full_unstemmed	Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
title_sort	blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55db22a305c6496f9b968f3910de8bf9
work_keys_str_mv	AT yanlu bloodglucoserelatedindicatorsareassociatedwithinhospitalmortalityincriticallyillpatientswithacutepancreatitis AT qiaohongzhang bloodglucoserelatedindicatorsareassociatedwithinhospitalmortalityincriticallyillpatientswithacutepancreatitis AT jianjielou bloodglucoserelatedindicatorsareassociatedwithinhospitalmortalityincriticallyillpatientswithacutepancreatitis
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Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis

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