Co-evolution of tumor and immune cells during progression of multiple myeloma

Co-evolution of tumor and immune cells during progression of multiple myeloma

Clonal evolution in multiple myeloma (MM) needs to be understood in both the tumor and its microenvironment. Here the authors perform single-cell multi-omics profiling of samples from MM patients at different stages, finding transitions in the immune cell composition throughout progression.

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Autores principales: Ruiyang Liu, Qingsong Gao, Steven M. Foltz, Jared S. Fowles, Lijun Yao, Julia Tianjiao Wang, Song Cao, Hua Sun, Michael C. Wendl, Sunantha Sethuraman, Amila Weerasinghe, Michael P. Rettig, Erik P. Storrs, Christopher J. Yoon, Matthew A. Wyczalkowski, Joshua F. McMichael, Daniel R. Kohnen, Justin King, Scott R. Goldsmith, Julie O’Neal, Robert S. Fulton, Catrina C. Fronick, Timothy J. Ley, Reyka G. Jayasinghe, Mark A. Fiala, Stephen T. Oh, John F. DiPersio, Ravi Vij, Li Ding
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/55db7fd3140a43c78fdc7b490f24992e
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spelling oai:doaj.org-article:55db7fd3140a43c78fdc7b490f24992e2021-12-02T16:49:06ZCo-evolution of tumor and immune cells during progression of multiple myeloma10.1038/s41467-021-22804-x2041-1723https://doaj.org/article/55db7fd3140a43c78fdc7b490f24992e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22804-xhttps://doaj.org/toc/2041-1723Clonal evolution in multiple myeloma (MM) needs to be understood in both the tumor and its microenvironment. Here the authors perform single-cell multi-omics profiling of samples from MM patients at different stages, finding transitions in the immune cell composition throughout progression.Ruiyang LiuQingsong GaoSteven M. FoltzJared S. FowlesLijun YaoJulia Tianjiao WangSong CaoHua SunMichael C. WendlSunantha SethuramanAmila WeerasingheMichael P. RettigErik P. StorrsChristopher J. YoonMatthew A. WyczalkowskiJoshua F. McMichaelDaniel R. KohnenJustin KingScott R. GoldsmithJulie O’NealRobert S. FultonCatrina C. FronickTimothy J. LeyReyka G. JayasingheMark A. FialaStephen T. OhJohn F. DiPersioRavi VijLi DingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ruiyang Liu
Qingsong Gao
Steven M. Foltz
Jared S. Fowles
Lijun Yao
Julia Tianjiao Wang
Song Cao
Hua Sun
Michael C. Wendl
Sunantha Sethuraman
Amila Weerasinghe
Michael P. Rettig
Erik P. Storrs
Christopher J. Yoon
Matthew A. Wyczalkowski
Joshua F. McMichael
Daniel R. Kohnen
Justin King
Scott R. Goldsmith
Julie O’Neal
Robert S. Fulton
Catrina C. Fronick
Timothy J. Ley
Reyka G. Jayasinghe
Mark A. Fiala
Stephen T. Oh
John F. DiPersio
Ravi Vij
Li Ding
Co-evolution of tumor and immune cells during progression of multiple myeloma
description Clonal evolution in multiple myeloma (MM) needs to be understood in both the tumor and its microenvironment. Here the authors perform single-cell multi-omics profiling of samples from MM patients at different stages, finding transitions in the immune cell composition throughout progression.
format article
author Ruiyang Liu
Qingsong Gao
Steven M. Foltz
Jared S. Fowles
Lijun Yao
Julia Tianjiao Wang
Song Cao
Hua Sun
Michael C. Wendl
Sunantha Sethuraman
Amila Weerasinghe
Michael P. Rettig
Erik P. Storrs
Christopher J. Yoon
Matthew A. Wyczalkowski
Joshua F. McMichael
Daniel R. Kohnen
Justin King
Scott R. Goldsmith
Julie O’Neal
Robert S. Fulton
Catrina C. Fronick
Timothy J. Ley
Reyka G. Jayasinghe
Mark A. Fiala
Stephen T. Oh
John F. DiPersio
Ravi Vij
Li Ding
author_facet Ruiyang Liu
Qingsong Gao
Steven M. Foltz
Jared S. Fowles
Lijun Yao
Julia Tianjiao Wang
Song Cao
Hua Sun
Michael C. Wendl
Sunantha Sethuraman
Amila Weerasinghe
Michael P. Rettig
Erik P. Storrs
Christopher J. Yoon
Matthew A. Wyczalkowski
Joshua F. McMichael
Daniel R. Kohnen
Justin King
Scott R. Goldsmith
Julie O’Neal
Robert S. Fulton
Catrina C. Fronick
Timothy J. Ley
Reyka G. Jayasinghe
Mark A. Fiala
Stephen T. Oh
John F. DiPersio
Ravi Vij
Li Ding
author_sort Ruiyang Liu
title Co-evolution of tumor and immune cells during progression of multiple myeloma
title_short Co-evolution of tumor and immune cells during progression of multiple myeloma
title_full Co-evolution of tumor and immune cells during progression of multiple myeloma
title_fullStr Co-evolution of tumor and immune cells during progression of multiple myeloma
title_full_unstemmed Co-evolution of tumor and immune cells during progression of multiple myeloma
title_sort co-evolution of tumor and immune cells during progression of multiple myeloma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/55db7fd3140a43c78fdc7b490f24992e
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