Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–c...

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Auteurs principaux:	Martijn Gloerich, Julie M. Bianchini, Kathleen A. Siemers, Daniel J. Cohen, W. James Nelson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d5
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id	oai:doaj.org-article:55dcdce0fb18402db21b35a74521e6d5
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spelling	oai:doaj.org-article:55dcdce0fb18402db21b35a74521e6d52021-12-02T14:42:17ZCell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex10.1038/ncomms139962041-1723https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d52017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13996https://doaj.org/toc/2041-1723Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.Martijn GloerichJulie M. BianchiniKathleen A. SiemersDaniel J. CohenW. James NelsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martijn Gloerich Julie M. Bianchini Kathleen A. Siemers Daniel J. Cohen W. James Nelson Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
description	Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.
format	article
author	Martijn Gloerich Julie M. Bianchini Kathleen A. Siemers Daniel J. Cohen W. James Nelson
author_facet	Martijn Gloerich Julie M. Bianchini Kathleen A. Siemers Daniel J. Cohen W. James Nelson
author_sort	Martijn Gloerich
title	Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_short	Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_full	Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_fullStr	Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_full_unstemmed	Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_sort	cell division orientation is coupled to cell–cell adhesion by the e-cadherin/lgn complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d5
work_keys_str_mv	AT martijngloerich celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT juliembianchini celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT kathleenasiemers celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT danieljcohen celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT wjamesnelson celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex
_version_	1718389749449752576

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

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