Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–c...

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Autores principales: Martijn Gloerich, Julie M. Bianchini, Kathleen A. Siemers, Daniel J. Cohen, W. James Nelson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d5
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spelling oai:doaj.org-article:55dcdce0fb18402db21b35a74521e6d52021-12-02T14:42:17ZCell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex10.1038/ncomms139962041-1723https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d52017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13996https://doaj.org/toc/2041-1723Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.Martijn GloerichJulie M. BianchiniKathleen A. SiemersDaniel J. CohenW. James NelsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martijn Gloerich
Julie M. Bianchini
Kathleen A. Siemers
Daniel J. Cohen
W. James Nelson
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
description Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.
format article
author Martijn Gloerich
Julie M. Bianchini
Kathleen A. Siemers
Daniel J. Cohen
W. James Nelson
author_facet Martijn Gloerich
Julie M. Bianchini
Kathleen A. Siemers
Daniel J. Cohen
W. James Nelson
author_sort Martijn Gloerich
title Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_short Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_full Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_fullStr Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_full_unstemmed Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
title_sort cell division orientation is coupled to cell–cell adhesion by the e-cadherin/lgn complex
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d5
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AT kathleenasiemers celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex
AT danieljcohen celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex
AT wjamesnelson celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex
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