Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex
Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–c...
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Nature Portfolio
2017
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oai:doaj.org-article:55dcdce0fb18402db21b35a74521e6d52021-12-02T14:42:17ZCell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex10.1038/ncomms139962041-1723https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d52017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13996https://doaj.org/toc/2041-1723Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.Martijn GloerichJulie M. BianchiniKathleen A. SiemersDaniel J. CohenW. James NelsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
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Science Q Martijn Gloerich Julie M. Bianchini Kathleen A. Siemers Daniel J. Cohen W. James Nelson Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex |
description |
Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle. |
format |
article |
author |
Martijn Gloerich Julie M. Bianchini Kathleen A. Siemers Daniel J. Cohen W. James Nelson |
author_facet |
Martijn Gloerich Julie M. Bianchini Kathleen A. Siemers Daniel J. Cohen W. James Nelson |
author_sort |
Martijn Gloerich |
title |
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex |
title_short |
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex |
title_full |
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex |
title_fullStr |
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex |
title_full_unstemmed |
Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex |
title_sort |
cell division orientation is coupled to cell–cell adhesion by the e-cadherin/lgn complex |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/55dcdce0fb18402db21b35a74521e6d5 |
work_keys_str_mv |
AT martijngloerich celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT juliembianchini celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT kathleenasiemers celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT danieljcohen celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex AT wjamesnelson celldivisionorientationiscoupledtocellcelladhesionbytheecadherinlgncomplex |
_version_ |
1718389749449752576 |