Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy

X-linked myotubular myopathy (XLMTM) is a severe muscle disease with no effective treatment. Here, the authors show that tamoxifen, a drug used to treat breast cancer, rescues the pathology in a mouse model of the disease, at least in part by normalizing expression of the disease modifier proteins D...

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Autores principales:	Elinam Gayi, Laurence A. Neff, Xènia Massana Muñoz, Hesham M. Ismail, Marta Sierra, Thomas Mercier, Laurent A. Décosterd, Jocelyn Laporte, Belinda S. Cowling, Olivier M. Dorchies, Leonardo Scapozza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55e31f0f62ce4d928b4e2b13a82b1d60
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spelling	oai:doaj.org-article:55e31f0f62ce4d928b4e2b13a82b1d602021-12-02T14:41:28ZTamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy10.1038/s41467-018-07058-42041-1723https://doaj.org/article/55e31f0f62ce4d928b4e2b13a82b1d602018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07058-4https://doaj.org/toc/2041-1723X-linked myotubular myopathy (XLMTM) is a severe muscle disease with no effective treatment. Here, the authors show that tamoxifen, a drug used to treat breast cancer, rescues the pathology in a mouse model of the disease, at least in part by normalizing expression of the disease modifier proteins DNM2 and BIN1Elinam GayiLaurence A. NeffXènia Massana MuñozHesham M. IsmailMarta SierraThomas MercierLaurent A. DécosterdJocelyn LaporteBelinda S. CowlingOlivier M. DorchiesLeonardo ScapozzaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elinam Gayi Laurence A. Neff Xènia Massana Muñoz Hesham M. Ismail Marta Sierra Thomas Mercier Laurent A. Décosterd Jocelyn Laporte Belinda S. Cowling Olivier M. Dorchies Leonardo Scapozza Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
description	X-linked myotubular myopathy (XLMTM) is a severe muscle disease with no effective treatment. Here, the authors show that tamoxifen, a drug used to treat breast cancer, rescues the pathology in a mouse model of the disease, at least in part by normalizing expression of the disease modifier proteins DNM2 and BIN1
format	article
author	Elinam Gayi Laurence A. Neff Xènia Massana Muñoz Hesham M. Ismail Marta Sierra Thomas Mercier Laurent A. Décosterd Jocelyn Laporte Belinda S. Cowling Olivier M. Dorchies Leonardo Scapozza
author_facet	Elinam Gayi Laurence A. Neff Xènia Massana Muñoz Hesham M. Ismail Marta Sierra Thomas Mercier Laurent A. Décosterd Jocelyn Laporte Belinda S. Cowling Olivier M. Dorchies Leonardo Scapozza
author_sort	Elinam Gayi
title	Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
title_short	Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
title_full	Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
title_fullStr	Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
title_full_unstemmed	Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy
title_sort	tamoxifen prolongs survival and alleviates symptoms in mice with fatal x-linked myotubular myopathy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/55e31f0f62ce4d928b4e2b13a82b1d60
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Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy

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