T regulatory cells are markers of disease activity in multiple sclerosis patients.

FoxP3⁺ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometr...

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Autores principales:	Dacia Dalla Libera, Diletta Di Mitri, Alessandra Bergami, Diego Centonze, Claudio Gasperini, Maria Grazia Grasso, Simona Galgani, Vittorio Martinelli, Giancarlo Comi, Carlo Avolio, Gianvito Martino, Giovanna Borsellino, Federica Sallusto, Luca Battistini, Roberto Furlan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55e58971970341adb513b3c08ee99c81
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spelling	oai:doaj.org-article:55e58971970341adb513b3c08ee99c812021-11-18T06:51:18ZT regulatory cells are markers of disease activity in multiple sclerosis patients.1932-620310.1371/journal.pone.0021386https://doaj.org/article/55e58971970341adb513b3c08ee99c812011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21731726/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203FoxP3⁺ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometry, and real-time RT-PCR, several Treg markers in peripheral blood mononuclear cells from patients with multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. We found that Tregs, as defined by CD25, CD39, FoxP3, CTLA4, and GITR expression, were significantly decreased in stable MS patients as compared to healthy donors, but, surprisingly, restored to normal levels during an acute clinical attack. We conclude that Treg cells are not involved in causing clinical relapses, but rather react to inflammation in the attempt to restore homeostasis.Dacia Dalla LiberaDiletta Di MitriAlessandra BergamiDiego CentonzeClaudio GasperiniMaria Grazia GrassoSimona GalganiVittorio MartinelliGiancarlo ComiCarlo AvolioGianvito MartinoGiovanna BorsellinoFederica SallustoLuca BattistiniRoberto FurlanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21386 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dacia Dalla Libera Diletta Di Mitri Alessandra Bergami Diego Centonze Claudio Gasperini Maria Grazia Grasso Simona Galgani Vittorio Martinelli Giancarlo Comi Carlo Avolio Gianvito Martino Giovanna Borsellino Federica Sallusto Luca Battistini Roberto Furlan T regulatory cells are markers of disease activity in multiple sclerosis patients.
description	FoxP3⁺ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometry, and real-time RT-PCR, several Treg markers in peripheral blood mononuclear cells from patients with multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. We found that Tregs, as defined by CD25, CD39, FoxP3, CTLA4, and GITR expression, were significantly decreased in stable MS patients as compared to healthy donors, but, surprisingly, restored to normal levels during an acute clinical attack. We conclude that Treg cells are not involved in causing clinical relapses, but rather react to inflammation in the attempt to restore homeostasis.
format	article
author	Dacia Dalla Libera Diletta Di Mitri Alessandra Bergami Diego Centonze Claudio Gasperini Maria Grazia Grasso Simona Galgani Vittorio Martinelli Giancarlo Comi Carlo Avolio Gianvito Martino Giovanna Borsellino Federica Sallusto Luca Battistini Roberto Furlan
author_facet	Dacia Dalla Libera Diletta Di Mitri Alessandra Bergami Diego Centonze Claudio Gasperini Maria Grazia Grasso Simona Galgani Vittorio Martinelli Giancarlo Comi Carlo Avolio Gianvito Martino Giovanna Borsellino Federica Sallusto Luca Battistini Roberto Furlan
author_sort	Dacia Dalla Libera
title	T regulatory cells are markers of disease activity in multiple sclerosis patients.
title_short	T regulatory cells are markers of disease activity in multiple sclerosis patients.
title_full	T regulatory cells are markers of disease activity in multiple sclerosis patients.
title_fullStr	T regulatory cells are markers of disease activity in multiple sclerosis patients.
title_full_unstemmed	T regulatory cells are markers of disease activity in multiple sclerosis patients.
title_sort	t regulatory cells are markers of disease activity in multiple sclerosis patients.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/55e58971970341adb513b3c08ee99c81
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T regulatory cells are markers of disease activity in multiple sclerosis patients.

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