Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

The underlying mechanism of amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release remains unclear. Here, authors show that the release probability at the synapse between the Schaffer collateral and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD wit...

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Autores principales:	Yang He, Mengdi Wei, Yan Wu, Huaping Qin, Weinan Li, Xiaolin Ma, Jingjing Cheng, Jinshuai Ren, Ye Shen, Zhong Chen, Binggui Sun, Fu-De Huang, Yi Shen, Yu-Dong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55e5dfe1d82d42c0af364801b3a94fc4
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spelling	oai:doaj.org-article:55e5dfe1d82d42c0af364801b3a94fc42021-12-02T17:01:47ZAmyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate10.1038/s41467-019-09114-z2041-1723https://doaj.org/article/55e5dfe1d82d42c0af364801b3a94fc42019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09114-zhttps://doaj.org/toc/2041-1723The underlying mechanism of amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release remains unclear. Here, authors show that the release probability at the synapse between the Schaffer collateral and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD with elevated Aβ production and is mainly due to an mGluR5-mediated depletion of PIP2 in axons.Yang HeMengdi WeiYan WuHuaping QinWeinan LiXiaolin MaJingjing ChengJinshuai RenYe ShenZhong ChenBinggui SunFu-De HuangYi ShenYu-Dong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang He Mengdi Wei Yan Wu Huaping Qin Weinan Li Xiaolin Ma Jingjing Cheng Jinshuai Ren Ye Shen Zhong Chen Binggui Sun Fu-De Huang Yi Shen Yu-Dong Zhou Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
description	The underlying mechanism of amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release remains unclear. Here, authors show that the release probability at the synapse between the Schaffer collateral and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD with elevated Aβ production and is mainly due to an mGluR5-mediated depletion of PIP2 in axons.
format	article
author	Yang He Mengdi Wei Yan Wu Huaping Qin Weinan Li Xiaolin Ma Jingjing Cheng Jinshuai Ren Ye Shen Zhong Chen Binggui Sun Fu-De Huang Yi Shen Yu-Dong Zhou
author_facet	Yang He Mengdi Wei Yan Wu Huaping Qin Weinan Li Xiaolin Ma Jingjing Cheng Jinshuai Ren Ye Shen Zhong Chen Binggui Sun Fu-De Huang Yi Shen Yu-Dong Zhou
author_sort	Yang He
title	Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
title_short	Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
title_full	Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
title_fullStr	Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
title_full_unstemmed	Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
title_sort	amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/55e5dfe1d82d42c0af364801b3a94fc4
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Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

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