Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population

BACKGROUND: In most countries, there is a rapid increase in the population of patients with type 2 Diabetes Mellitus (DM). Bone changes in postmenopausal women with type 2 DM are associated with increased bone mineral density (BMD). The study of metabolic processes in bone tissue in comorbid patholo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tatiana P. Bardymova, Maksim V. Mistiakov, Galina P. Yagelskaya
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	diabetes mellitus, type 2 bone remodeling ethnicity Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/55e8758caa954d77aecc80f9ae106548
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:55e8758caa954d77aecc80f9ae106548
record_format	dspace
spelling	oai:doaj.org-article:55e8758caa954d77aecc80f9ae1065482021-11-14T09:00:22ZCondition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population2072-03512072-037810.14341/DM10310https://doaj.org/article/55e8758caa954d77aecc80f9ae1065482019-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10310https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: In most countries, there is a rapid increase in the population of patients with type 2 Diabetes Mellitus (DM). Bone changes in postmenopausal women with type 2 DM are associated with increased bone mineral density (BMD). The study of metabolic processes in bone tissue in comorbid pathology in different ethnic groups is continuing. AIMS: To study the concentration of markers of bone remodeling and indicators of BMD in postmenopausal women with type 2 DM of the Buryat population. MATERIALS AND METHODS: Thirty-nine postmenopausal women with type 2 DM (22 – Russian population and 17 – Buryat population) were examined. The comparison group consisted of 42 postmenopausal women (21 – Russian population and 21 - Buryat population). The study of BMD in the lumbar spine (L1-L4), the femoral neck (Neck), and the proximal femur (Total hip) was performed using dual-energy X-ray absorptiometry. Parameters of osteocalcin (OC), type 1 N-terminal procollagen propeptide (P1NP), C-terminal telopeptides of type I collagen (β-Cross laps), 25(OH) vitamin D and ionized calcium were evaluated. RESULTS: The presented study revealed a simultaneous increase in osteosynthesis: ОС (p=0.048) and P1NP (p=0.016) and in the bone resorption marker β-Cross laps (p=0.020) accompanied by the absence of changes in BMD in women with type 2 DM in the postmenopausal period of the Buryat population relative to women with type 2 DM in the postmenopausal state of the Russian population. A decrease in osteosynthesis parameters (ОC, p=0.021; P1NP, p=0.029) with an increase in BMD L1-L4 (p=0.024) and BMD Total hip (p=0.039) in postmenopausal women with type 2 DM of the Buryat population was found relative to the women of the Buryat population in comparison group. CONCLUSIONS: The state of bone tissue in postmenopausal women with type 2 DM of the Buryat population is characterized by the activation of bone remodeling processes.Tatiana P. BardymovaMaksim V. MistiakovGalina P. YagelskayaEndocrinology Research Centrearticlediabetes mellitus, type 2bone remodelingethnicityNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 5, Pp 436-443 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus, type 2 bone remodeling ethnicity Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus, type 2 bone remodeling ethnicity Nutritional diseases. Deficiency diseases RC620-627 Tatiana P. Bardymova Maksim V. Mistiakov Galina P. Yagelskaya Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population
description	BACKGROUND: In most countries, there is a rapid increase in the population of patients with type 2 Diabetes Mellitus (DM). Bone changes in postmenopausal women with type 2 DM are associated with increased bone mineral density (BMD). The study of metabolic processes in bone tissue in comorbid pathology in different ethnic groups is continuing. AIMS: To study the concentration of markers of bone remodeling and indicators of BMD in postmenopausal women with type 2 DM of the Buryat population. MATERIALS AND METHODS: Thirty-nine postmenopausal women with type 2 DM (22 – Russian population and 17 – Buryat population) were examined. The comparison group consisted of 42 postmenopausal women (21 – Russian population and 21 - Buryat population). The study of BMD in the lumbar spine (L1-L4), the femoral neck (Neck), and the proximal femur (Total hip) was performed using dual-energy X-ray absorptiometry. Parameters of osteocalcin (OC), type 1 N-terminal procollagen propeptide (P1NP), C-terminal telopeptides of type I collagen (β-Cross laps), 25(OH) vitamin D and ionized calcium were evaluated. RESULTS: The presented study revealed a simultaneous increase in osteosynthesis: ОС (p=0.048) and P1NP (p=0.016) and in the bone resorption marker β-Cross laps (p=0.020) accompanied by the absence of changes in BMD in women with type 2 DM in the postmenopausal period of the Buryat population relative to women with type 2 DM in the postmenopausal state of the Russian population. A decrease in osteosynthesis parameters (ОC, p=0.021; P1NP, p=0.029) with an increase in BMD L1-L4 (p=0.024) and BMD Total hip (p=0.039) in postmenopausal women with type 2 DM of the Buryat population was found relative to the women of the Buryat population in comparison group. CONCLUSIONS: The state of bone tissue in postmenopausal women with type 2 DM of the Buryat population is characterized by the activation of bone remodeling processes.
format	article
author	Tatiana P. Bardymova Maksim V. Mistiakov Galina P. Yagelskaya
author_facet	Tatiana P. Bardymova Maksim V. Mistiakov Galina P. Yagelskaya
author_sort	Tatiana P. Bardymova
title	Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population
title_short	Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population
title_full	Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population
title_fullStr	Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population
title_full_unstemmed	Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population
title_sort	condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of buryat population
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/55e8758caa954d77aecc80f9ae106548
work_keys_str_mv	AT tatianapbardymova conditionofbonetissueinpostmenopausalwomenwithtype2diabetesmellitusofburyatpopulation AT maksimvmistiakov conditionofbonetissueinpostmenopausalwomenwithtype2diabetesmellitusofburyatpopulation AT galinapyagelskaya conditionofbonetissueinpostmenopausalwomenwithtype2diabetesmellitusofburyatpopulation
_version_	1718429528007639040

Condition of bone tissue in postmenopausal women with type 2 diabetes mellitus of Buryat population

Ejemplares similares