BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is characterised by progressive muscle degeneration. Here, the authors show that the BET protein BRD4 is increased in the muscle of DMD mouse models, and that pharmacological inhibition of BRD4 leads to reduced muscle pathology in mice, by modulating NADPH oxidase e...

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Autores principales:	Marco Segatto, Roberta Szokoll, Raffaella Fittipaldi, Cinzia Bottino, Lorenzo Nevi, Kamel Mamchaoui, Panagis Filippakopoulos, Giuseppina Caretti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55e92e9f04a24679a1d5b129a0da42cf
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spelling	oai:doaj.org-article:55e92e9f04a24679a1d5b129a0da42cf2021-12-02T14:40:30ZBETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy10.1038/s41467-020-19839-x2041-1723https://doaj.org/article/55e92e9f04a24679a1d5b129a0da42cf2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19839-xhttps://doaj.org/toc/2041-1723Duchenne muscular dystrophy (DMD) is characterised by progressive muscle degeneration. Here, the authors show that the BET protein BRD4 is increased in the muscle of DMD mouse models, and that pharmacological inhibition of BRD4 leads to reduced muscle pathology in mice, by modulating NADPH oxidase expression.Marco SegattoRoberta SzokollRaffaella FittipaldiCinzia BottinoLorenzo NeviKamel MamchaouiPanagis FilippakopoulosGiuseppina CarettiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Segatto Roberta Szokoll Raffaella Fittipaldi Cinzia Bottino Lorenzo Nevi Kamel Mamchaoui Panagis Filippakopoulos Giuseppina Caretti BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
description	Duchenne muscular dystrophy (DMD) is characterised by progressive muscle degeneration. Here, the authors show that the BET protein BRD4 is increased in the muscle of DMD mouse models, and that pharmacological inhibition of BRD4 leads to reduced muscle pathology in mice, by modulating NADPH oxidase expression.
format	article
author	Marco Segatto Roberta Szokoll Raffaella Fittipaldi Cinzia Bottino Lorenzo Nevi Kamel Mamchaoui Panagis Filippakopoulos Giuseppina Caretti
author_facet	Marco Segatto Roberta Szokoll Raffaella Fittipaldi Cinzia Bottino Lorenzo Nevi Kamel Mamchaoui Panagis Filippakopoulos Giuseppina Caretti
author_sort	Marco Segatto
title	BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
title_short	BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
title_full	BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
title_fullStr	BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
title_full_unstemmed	BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
title_sort	bets inhibition attenuates oxidative stress and preserves muscle integrity in duchenne muscular dystrophy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/55e92e9f04a24679a1d5b129a0da42cf
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BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

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