TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibroblasts that appear after anti-TGFβ treatment.

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Autores principales:	Angelo L. Grauel, Beverly Nguyen, David Ruddy, Tyler Laszewski, Stephanie Schwartz, Jonathan Chang, Julie Chen, Michelle Piquet, Marc Pelletier, Zheng Yan, Nathaniel D. Kirkpatrick, Jincheng Wu, Antoine deWeck, Markus Riester, Matt Hims, Felipe Correa Geyer, Joel Wagner, Kenzie MacIsaac, James Deeds, Rohan Diwanji, Pushpa Jayaraman, Yenyen Yu, Quincey Simmons, Shaobu Weng, Alina Raza, Brian Minie, Mirek Dostalek, Pavitra Chikkegowda, Vera Ruda, Oleg Iartchouk, Naiyan Chen, Raphael Thierry, Joseph Zhou, Iulian Pruteanu-Malinici, Claire Fabre, Jeffrey A. Engelman, Glenn Dranoff, Viviana Cremasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55eb6b2ee746490ba919c1fb7bbcfb1d
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spelling	oai:doaj.org-article:55eb6b2ee746490ba919c1fb7bbcfb1d2021-12-02T13:24:34ZTGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts10.1038/s41467-020-19920-52041-1723https://doaj.org/article/55eb6b2ee746490ba919c1fb7bbcfb1d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19920-5https://doaj.org/toc/2041-1723Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibroblasts that appear after anti-TGFβ treatment.Angelo L. GrauelBeverly NguyenDavid RuddyTyler LaszewskiStephanie SchwartzJonathan ChangJulie ChenMichelle PiquetMarc PelletierZheng YanNathaniel D. KirkpatrickJincheng WuAntoine deWeckMarkus RiesterMatt HimsFelipe Correa GeyerJoel WagnerKenzie MacIsaacJames DeedsRohan DiwanjiPushpa JayaramanYenyen YuQuincey SimmonsShaobu WengAlina RazaBrian MinieMirek DostalekPavitra ChikkegowdaVera RudaOleg IartchoukNaiyan ChenRaphael ThierryJoseph ZhouIulian Pruteanu-MaliniciClaire FabreJeffrey A. EngelmanGlenn DranoffViviana CremascoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angelo L. Grauel Beverly Nguyen David Ruddy Tyler Laszewski Stephanie Schwartz Jonathan Chang Julie Chen Michelle Piquet Marc Pelletier Zheng Yan Nathaniel D. Kirkpatrick Jincheng Wu Antoine deWeck Markus Riester Matt Hims Felipe Correa Geyer Joel Wagner Kenzie MacIsaac James Deeds Rohan Diwanji Pushpa Jayaraman Yenyen Yu Quincey Simmons Shaobu Weng Alina Raza Brian Minie Mirek Dostalek Pavitra Chikkegowda Vera Ruda Oleg Iartchouk Naiyan Chen Raphael Thierry Joseph Zhou Iulian Pruteanu-Malinici Claire Fabre Jeffrey A. Engelman Glenn Dranoff Viviana Cremasco TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
description	Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibroblasts that appear after anti-TGFβ treatment.
format	article
author	Angelo L. Grauel Beverly Nguyen David Ruddy Tyler Laszewski Stephanie Schwartz Jonathan Chang Julie Chen Michelle Piquet Marc Pelletier Zheng Yan Nathaniel D. Kirkpatrick Jincheng Wu Antoine deWeck Markus Riester Matt Hims Felipe Correa Geyer Joel Wagner Kenzie MacIsaac James Deeds Rohan Diwanji Pushpa Jayaraman Yenyen Yu Quincey Simmons Shaobu Weng Alina Raza Brian Minie Mirek Dostalek Pavitra Chikkegowda Vera Ruda Oleg Iartchouk Naiyan Chen Raphael Thierry Joseph Zhou Iulian Pruteanu-Malinici Claire Fabre Jeffrey A. Engelman Glenn Dranoff Viviana Cremasco
author_facet	Angelo L. Grauel Beverly Nguyen David Ruddy Tyler Laszewski Stephanie Schwartz Jonathan Chang Julie Chen Michelle Piquet Marc Pelletier Zheng Yan Nathaniel D. Kirkpatrick Jincheng Wu Antoine deWeck Markus Riester Matt Hims Felipe Correa Geyer Joel Wagner Kenzie MacIsaac James Deeds Rohan Diwanji Pushpa Jayaraman Yenyen Yu Quincey Simmons Shaobu Weng Alina Raza Brian Minie Mirek Dostalek Pavitra Chikkegowda Vera Ruda Oleg Iartchouk Naiyan Chen Raphael Thierry Joseph Zhou Iulian Pruteanu-Malinici Claire Fabre Jeffrey A. Engelman Glenn Dranoff Viviana Cremasco
author_sort	Angelo L. Grauel
title	TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
title_short	TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
title_full	TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
title_fullStr	TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
title_full_unstemmed	TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
title_sort	tgfβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/55eb6b2ee746490ba919c1fb7bbcfb1d
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TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

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