Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites

The dissolution of poorly water-soluble drug poses a big challenge to the researchers in drug discovery. Electrospun nanofibers have been broadly demonstrated as good candidates for resolving this issue. However, the testing methods are often indiscriminate with the drug sustained release profiles....

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Autores principales:	Yingfu Bai, Di Wang, Zhi Zhang, Jincheng Pan, Zhengbo Cui, Deng-Guang Yu, Sim-Wan Annie Bligh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Polymeric nanocomposite Amorphous Hydrophilic Electrospinning Fast dissolution Polymer testing Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/55f196ae66444dec90f488158b1857e2
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spelling	oai:doaj.org-article:55f196ae66444dec90f488158b1857e22021-11-24T04:23:33ZTesting of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites0142-941810.1016/j.polymertesting.2020.106872https://doaj.org/article/55f196ae66444dec90f488158b1857e22021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0142941820321012https://doaj.org/toc/0142-9418The dissolution of poorly water-soluble drug poses a big challenge to the researchers in drug discovery. Electrospun nanofibers have been broadly demonstrated as good candidates for resolving this issue. However, the testing methods are often indiscriminate with the drug sustained release profiles. In this study, a new coaxial solid core spinneret was developed to carry out the preparation of ibuprofen (IBU)-loaded polyvinylpyrrolidone (PVP) nanofibers. These nanofibers have an average diameter of 740 ± 130 nm with linear morphology, smooth surface and smooth cross-section without any solid phase separation, as verified by SEM images. XRD and DSC results suggested that IBU presented in the fibers in an amorphous state thanks to their fine compatibility, as disclosed by FTIR spectra. Four different methods (a polarized microscope, an artificial tongue, a contact angle meter, and the in vitro dissolution tests) are exploited to assess the fast dissolution properties of the fibers. Their results concurred the fine functional performances of electrospun nanofibers on improving the dissolution rate of IBU from different standpoints, with 100.3 ± 4.2% of the loaded IBU freed into the dissolution media within the first minute. They are synergistic effects of hydrophilic polymer, large surface and porosity of electrospun nanofiber mats, and amorphous state of the drug.Yingfu BaiDi WangZhi ZhangJincheng PanZhengbo CuiDeng-Guang YuSim-Wan Annie BlighElsevierarticlePolymeric nanocompositeAmorphousHydrophilicElectrospinningFast dissolutionPolymer testingPolymers and polymer manufactureTP1080-1185ENPolymer Testing, Vol 93, Iss , Pp 106872- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polymeric nanocomposite Amorphous Hydrophilic Electrospinning Fast dissolution Polymer testing Polymers and polymer manufacture TP1080-1185
spellingShingle	Polymeric nanocomposite Amorphous Hydrophilic Electrospinning Fast dissolution Polymer testing Polymers and polymer manufacture TP1080-1185 Yingfu Bai Di Wang Zhi Zhang Jincheng Pan Zhengbo Cui Deng-Guang Yu Sim-Wan Annie Bligh Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
description	The dissolution of poorly water-soluble drug poses a big challenge to the researchers in drug discovery. Electrospun nanofibers have been broadly demonstrated as good candidates for resolving this issue. However, the testing methods are often indiscriminate with the drug sustained release profiles. In this study, a new coaxial solid core spinneret was developed to carry out the preparation of ibuprofen (IBU)-loaded polyvinylpyrrolidone (PVP) nanofibers. These nanofibers have an average diameter of 740 ± 130 nm with linear morphology, smooth surface and smooth cross-section without any solid phase separation, as verified by SEM images. XRD and DSC results suggested that IBU presented in the fibers in an amorphous state thanks to their fine compatibility, as disclosed by FTIR spectra. Four different methods (a polarized microscope, an artificial tongue, a contact angle meter, and the in vitro dissolution tests) are exploited to assess the fast dissolution properties of the fibers. Their results concurred the fine functional performances of electrospun nanofibers on improving the dissolution rate of IBU from different standpoints, with 100.3 ± 4.2% of the loaded IBU freed into the dissolution media within the first minute. They are synergistic effects of hydrophilic polymer, large surface and porosity of electrospun nanofiber mats, and amorphous state of the drug.
format	article
author	Yingfu Bai Di Wang Zhi Zhang Jincheng Pan Zhengbo Cui Deng-Guang Yu Sim-Wan Annie Bligh
author_facet	Yingfu Bai Di Wang Zhi Zhang Jincheng Pan Zhengbo Cui Deng-Guang Yu Sim-Wan Annie Bligh
author_sort	Yingfu Bai
title	Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
title_short	Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
title_full	Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
title_fullStr	Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
title_full_unstemmed	Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
title_sort	testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/55f196ae66444dec90f488158b1857e2
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Testing of fast dissolution of ibuprofen from its electrospun hydrophilic polymer nanocomposites

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