The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators

The resolution of inflammation is an integral part of the acute inflammatory response and eventually leads to the return to homeostasis. It is supported by specialized pro-resolving mediators (SPMs) that act as immunoresolvents via specific G-protein-coupled receptors. In contrast to classical non-s...

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Autores principales:	Paul M. Jordan, Emeline van Goethem, Andrea M. Müller, Kathrin Hemmer, Virginie Gavioli, Vincent Baillif, Yvonne Burmeister, Natascha Krömmelbein, Marc Dubourdeau, Bernd Seilheimer, Oliver Werz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lipid mediator specialized pro-resolving mediators resolution index inflammation efferocytosis peritonitis Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/55f1d332c147488e8241f5eb2dfdd6dc
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spelling	oai:doaj.org-article:55f1d332c147488e8241f5eb2dfdd6dc2021-11-25T18:39:31ZThe Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators10.3390/ph141111231424-8247https://doaj.org/article/55f1d332c147488e8241f5eb2dfdd6dc2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1123https://doaj.org/toc/1424-8247The resolution of inflammation is an integral part of the acute inflammatory response and eventually leads to the return to homeostasis. It is supported by specialized pro-resolving mediators (SPMs) that act as immunoresolvents via specific G-protein-coupled receptors. In contrast to classical non-steroidal anti-inflammatory drugs (NSAIDs) that suppress the formation of pro-inflammatory lipid mediators such as prostaglandins, novel pharmacotherapeutic concepts propose to foster the biosynthesis of beneficial SPMs. Here, we demonstrate that the natural combination medicine Traumeel (Tr14) improves resolution of inflammation by promoting SPM formation. Tr14 enhanced the biosynthesis of 12-/15-lipoxygenase (LOX) products and of SPMs in zymosan-induced mouse peritonitis as well as in human monocyte-derived macrophages challenged with <i>Staphylococcus aureus</i>. Importantly, in the peritonitis model, Tr14 supported the recruitment of innate leukocytes and the efferocytotic capacity of macrophages, and positively influenced the inflammation resolution index. Taken together, we suggest that based on these properties Tr14 may possess therapeutic potential as an enhancer for the resolution of inflammatory processes.Paul M. JordanEmeline van GoethemAndrea M. MüllerKathrin HemmerVirginie GavioliVincent BaillifYvonne BurmeisterNatascha KrömmelbeinMarc DubourdeauBernd SeilheimerOliver WerzMDPI AGarticlelipid mediatorspecialized pro-resolving mediatorsresolution indexinflammationefferocytosisperitonitisMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1123, p 1123 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipid mediator specialized pro-resolving mediators resolution index inflammation efferocytosis peritonitis Medicine R Pharmacy and materia medica RS1-441
spellingShingle	lipid mediator specialized pro-resolving mediators resolution index inflammation efferocytosis peritonitis Medicine R Pharmacy and materia medica RS1-441 Paul M. Jordan Emeline van Goethem Andrea M. Müller Kathrin Hemmer Virginie Gavioli Vincent Baillif Yvonne Burmeister Natascha Krömmelbein Marc Dubourdeau Bernd Seilheimer Oliver Werz The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
description	The resolution of inflammation is an integral part of the acute inflammatory response and eventually leads to the return to homeostasis. It is supported by specialized pro-resolving mediators (SPMs) that act as immunoresolvents via specific G-protein-coupled receptors. In contrast to classical non-steroidal anti-inflammatory drugs (NSAIDs) that suppress the formation of pro-inflammatory lipid mediators such as prostaglandins, novel pharmacotherapeutic concepts propose to foster the biosynthesis of beneficial SPMs. Here, we demonstrate that the natural combination medicine Traumeel (Tr14) improves resolution of inflammation by promoting SPM formation. Tr14 enhanced the biosynthesis of 12-/15-lipoxygenase (LOX) products and of SPMs in zymosan-induced mouse peritonitis as well as in human monocyte-derived macrophages challenged with <i>Staphylococcus aureus</i>. Importantly, in the peritonitis model, Tr14 supported the recruitment of innate leukocytes and the efferocytotic capacity of macrophages, and positively influenced the inflammation resolution index. Taken together, we suggest that based on these properties Tr14 may possess therapeutic potential as an enhancer for the resolution of inflammatory processes.
format	article
author	Paul M. Jordan Emeline van Goethem Andrea M. Müller Kathrin Hemmer Virginie Gavioli Vincent Baillif Yvonne Burmeister Natascha Krömmelbein Marc Dubourdeau Bernd Seilheimer Oliver Werz
author_facet	Paul M. Jordan Emeline van Goethem Andrea M. Müller Kathrin Hemmer Virginie Gavioli Vincent Baillif Yvonne Burmeister Natascha Krömmelbein Marc Dubourdeau Bernd Seilheimer Oliver Werz
author_sort	Paul M. Jordan
title	The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
title_short	The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
title_full	The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
title_fullStr	The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
title_full_unstemmed	The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
title_sort	natural combination medicine traumeel (tr14) improves resolution of inflammation by promoting the biosynthesis of specialized pro-resolving mediators
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55f1d332c147488e8241f5eb2dfdd6dc
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The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators

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