Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.

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Autores principales:	Sharan Paul, Warunee Dansithong, Karla P. Figueroa, Daniel R. Scoles, Stefan M. Pulst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55f49f6a513e4819a5bfa825f7bb68a4
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spelling	oai:doaj.org-article:55f49f6a513e4819a5bfa825f7bb68a42021-12-02T15:34:07ZStaufen1 links RNA stress granules and autophagy in a model of neurodegeneration10.1038/s41467-018-06041-32041-1723https://doaj.org/article/55f49f6a513e4819a5bfa825f7bb68a42018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06041-3https://doaj.org/toc/2041-1723Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.Sharan PaulWarunee DansithongKarla P. FigueroaDaniel R. ScolesStefan M. PulstNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sharan Paul Warunee Dansithong Karla P. Figueroa Daniel R. Scoles Stefan M. Pulst Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
description	Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.
format	article
author	Sharan Paul Warunee Dansithong Karla P. Figueroa Daniel R. Scoles Stefan M. Pulst
author_facet	Sharan Paul Warunee Dansithong Karla P. Figueroa Daniel R. Scoles Stefan M. Pulst
author_sort	Sharan Paul
title	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_short	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_full	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_fullStr	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_full_unstemmed	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_sort	staufen1 links rna stress granules and autophagy in a model of neurodegeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/55f49f6a513e4819a5bfa825f7bb68a4
work_keys_str_mv	AT sharanpaul staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT waruneedansithong staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT karlapfigueroa staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT danielrscoles staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT stefanmpulst staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration
_version_	1718386899848003584

Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

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