Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.

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Autores principales: Sharan Paul, Warunee Dansithong, Karla P. Figueroa, Daniel R. Scoles, Stefan M. Pulst
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/55f49f6a513e4819a5bfa825f7bb68a4
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