A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments

ABSTRACT Severe malaria is a density-dependent disease that comprises infected-erythrocyte sequestration, with or without monocytic infiltration, as seen in renal, placental, and lung tissues from severe malaria patients. HIV induces a chronic proinflammatory state with higher numbers of inflammasom...

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Autor principal:	David J. Sullivan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/55f6aecff4674c9fbe51d03b7329b909
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spelling	oai:doaj.org-article:55f6aecff4674c9fbe51d03b7329b9092021-11-15T15:41:24ZA Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments10.1128/mBio.01818-152150-7511https://doaj.org/article/55f6aecff4674c9fbe51d03b7329b9092015-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01818-15https://doaj.org/toc/2150-7511ABSTRACT Severe malaria is a density-dependent disease that comprises infected-erythrocyte sequestration, with or without monocytic infiltration, as seen in renal, placental, and lung tissues from severe malaria patients. HIV induces a chronic proinflammatory state with higher numbers of inflammasome-activated monocytes and platelets circulating. The epidemiological and pathological study of S. E. Hochman et al. that was published in a recent issue of mBio (Hochman SE, Madaline TF, Wassmer SC, Mbale E, Choi N, et al., mBio 6:e01390-15, 2015, doi:10.1128/mBio.01390-15) analyzes a large cohort of Malawian children and shows that cerebral malaria in younger HIV-negative children presents as an acute disease predominated by sequestered infected erythrocytes. In contrast, they show that case presentation in older HIV-positive children is as a more lethal acute on chronic disease marked by double the monocytic infiltrates and 5 times as many platelets. This study suggests that cerebral involvement in severe malaria is a pathology similar to that of other organ involvement of severe malaria, with a bias in HIV-positive individuals toward more monocytic infiltrates. The study also addresses the important association of severe malaria and HIV prevalence.David J. SullivanAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 6 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 David J. Sullivan A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments
description	ABSTRACT Severe malaria is a density-dependent disease that comprises infected-erythrocyte sequestration, with or without monocytic infiltration, as seen in renal, placental, and lung tissues from severe malaria patients. HIV induces a chronic proinflammatory state with higher numbers of inflammasome-activated monocytes and platelets circulating. The epidemiological and pathological study of S. E. Hochman et al. that was published in a recent issue of mBio (Hochman SE, Madaline TF, Wassmer SC, Mbale E, Choi N, et al., mBio 6:e01390-15, 2015, doi:10.1128/mBio.01390-15) analyzes a large cohort of Malawian children and shows that cerebral malaria in younger HIV-negative children presents as an acute disease predominated by sequestered infected erythrocytes. In contrast, they show that case presentation in older HIV-positive children is as a more lethal acute on chronic disease marked by double the monocytic infiltrates and 5 times as many platelets. This study suggests that cerebral involvement in severe malaria is a pathology similar to that of other organ involvement of severe malaria, with a bias in HIV-positive individuals toward more monocytic infiltrates. The study also addresses the important association of severe malaria and HIV prevalence.
format	article
author	David J. Sullivan
author_facet	David J. Sullivan
author_sort	David J. Sullivan
title	A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments
title_short	A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments
title_full	A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments
title_fullStr	A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments
title_full_unstemmed	A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments
title_sort	single human cerebral malaria histopathologic study can be worth a thousand experiments
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/55f6aecff4674c9fbe51d03b7329b909
work_keys_str_mv	AT davidjsullivan asinglehumancerebralmalariahistopathologicstudycanbeworthathousandexperiments AT davidjsullivan singlehumancerebralmalariahistopathologicstudycanbeworthathousandexperiments
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A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments

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