Effects of personality on the association between paroxetine plasma concentration and response

Tetsu Tomita,1 Norio Yasui-Furukori,1 Taku Nakagami,2 Shoko Tsuchimine,3 Masamichi Ishioka,4 Ayako Kaneda,1 Kazuhiko Nakamura1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 2Department of Psychiatry, Nakagami Mental Clinic, Odate, Japan; 3Departm...

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Autores principales:	Tomita T, Yasui-Furukori N, Nakagami T, Tsuchimine S, Ishioka M, Kaneda A, Nakamura K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	depression paroxetine concentration personality Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/55f70432ff5f4148885d2d0670e2a68d
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spelling	oai:doaj.org-article:55f70432ff5f4148885d2d0670e2a68d2021-12-02T07:10:46ZEffects of personality on the association between paroxetine plasma concentration and response1178-2021https://doaj.org/article/55f70432ff5f4148885d2d0670e2a68d2018-11-01T00:00:00Zhttps://www.dovepress.com/effects-of-personality-on-the-association-between-paroxetine-plasma-co-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tetsu Tomita,1 Norio Yasui-Furukori,1 Taku Nakagami,2 Shoko Tsuchimine,3 Masamichi Ishioka,4 Ayako Kaneda,1 Kazuhiko Nakamura1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 2Department of Psychiatry, Nakagami Mental Clinic, Odate, Japan; 3Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan; 4Department of Psychiatry, Minato Hospital, Hachinohe, Japan Background: We studied the differences between groups that were divided according to personality characteristics with respect to the relationship between drug concentration and symptom improvement.Methods: A total of 120 patients with major depressive disorder were treated with paroxetine for 6 weeks, and 89 patients completed the protocol. The Montgomery–Åsberg Depression Rating Scale (MADRS) was used to evaluate the patients. Patients’ paroxetine plasma concentrations at week 6 were measured. Their personalities were evaluated by the Temperament and Character Inventory (TCI) at the first visit. We divided the patients into two groups according to the median of each TCI dimension. We compared the responder rate between “high” and “low” groups in each TCI dimension and analyzed Pearson’s correlation coefficients of paroxetine plasma concentration and MADRS-improvement rate.Results: A total of 62 patients completed the TCI. Low-novelty-seeking, high-harm-avoidance, low-reward-dependence, and low-self-directedness groups exhibited significant negative correlations between paroxetine plasma concentration and MADRS improvement. Among the groups with combined personality traits, the high-harm-avoidance and low-self-directedness groups showed a markedly significant negative correlation.Conclusion: Patients with depression exhibiting specific personality traits, especially those with high harm-avoidance and low self-directedness scores, exhibited a significant negative association between paroxetine plasma concentration and MADRS-improvement rate. Therefore, a lower dose might be suitable for patients with specific personality traits. Keywords: depression, paroxetine, concentration, personality, Temperament and Character Inventory, TCI Tomita TYasui-Furukori NNakagami TTsuchimine SIshioka MKaneda ANakamura KDove Medical PressarticledepressionparoxetineconcentrationpersonalityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3299-3306 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression paroxetine concentration personality Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression paroxetine concentration personality Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tomita T Yasui-Furukori N Nakagami T Tsuchimine S Ishioka M Kaneda A Nakamura K Effects of personality on the association between paroxetine plasma concentration and response
description	Tetsu Tomita,1 Norio Yasui-Furukori,1 Taku Nakagami,2 Shoko Tsuchimine,3 Masamichi Ishioka,4 Ayako Kaneda,1 Kazuhiko Nakamura1 1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 2Department of Psychiatry, Nakagami Mental Clinic, Odate, Japan; 3Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan; 4Department of Psychiatry, Minato Hospital, Hachinohe, Japan Background: We studied the differences between groups that were divided according to personality characteristics with respect to the relationship between drug concentration and symptom improvement.Methods: A total of 120 patients with major depressive disorder were treated with paroxetine for 6 weeks, and 89 patients completed the protocol. The Montgomery–Åsberg Depression Rating Scale (MADRS) was used to evaluate the patients. Patients’ paroxetine plasma concentrations at week 6 were measured. Their personalities were evaluated by the Temperament and Character Inventory (TCI) at the first visit. We divided the patients into two groups according to the median of each TCI dimension. We compared the responder rate between “high” and “low” groups in each TCI dimension and analyzed Pearson’s correlation coefficients of paroxetine plasma concentration and MADRS-improvement rate.Results: A total of 62 patients completed the TCI. Low-novelty-seeking, high-harm-avoidance, low-reward-dependence, and low-self-directedness groups exhibited significant negative correlations between paroxetine plasma concentration and MADRS improvement. Among the groups with combined personality traits, the high-harm-avoidance and low-self-directedness groups showed a markedly significant negative correlation.Conclusion: Patients with depression exhibiting specific personality traits, especially those with high harm-avoidance and low self-directedness scores, exhibited a significant negative association between paroxetine plasma concentration and MADRS-improvement rate. Therefore, a lower dose might be suitable for patients with specific personality traits. Keywords: depression, paroxetine, concentration, personality, Temperament and Character Inventory, TCI
format	article
author	Tomita T Yasui-Furukori N Nakagami T Tsuchimine S Ishioka M Kaneda A Nakamura K
author_facet	Tomita T Yasui-Furukori N Nakagami T Tsuchimine S Ishioka M Kaneda A Nakamura K
author_sort	Tomita T
title	Effects of personality on the association between paroxetine plasma concentration and response
title_short	Effects of personality on the association between paroxetine plasma concentration and response
title_full	Effects of personality on the association between paroxetine plasma concentration and response
title_fullStr	Effects of personality on the association between paroxetine plasma concentration and response
title_full_unstemmed	Effects of personality on the association between paroxetine plasma concentration and response
title_sort	effects of personality on the association between paroxetine plasma concentration and response
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/55f70432ff5f4148885d2d0670e2a68d
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_version_	1718399569611456512

Effects of personality on the association between paroxetine plasma concentration and response

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