In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system

Min-ting Wang1, Yun Jin1, Yun-xia Yang2, Chun-yan Zhao1, Hong-Yun Yang1, Xue-fan Xu1, Xuan Qin1, Zhao-dan Wang2, Zhi-Rong Zhang1, Yan-lin Jian3, Yuan Huang11Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, 2West China School of Preclini...

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Autores principales:	Min-ting Wang, Yun Jin, Yun-xia Yang, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/55fa116eb350455b93821eaa75d79583
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spelling	oai:doaj.org-article:55fa116eb350455b93821eaa75d795832021-12-02T03:05:14ZIn vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system1176-91141178-2013https://doaj.org/article/55fa116eb350455b93821eaa75d795832010-07-01T00:00:00Zhttp://www.dovepress.com/in-vivo-biodistribution-anti-inflammatory-and-hepatoprotective-effects-a4888https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Min-ting Wang1, Yun Jin1, Yun-xia Yang2, Chun-yan Zhao1, Hong-Yun Yang1, Xue-fan Xu1, Xuan Qin1, Zhao-dan Wang2, Zhi-Rong Zhang1, Yan-lin Jian3, Yuan Huang11Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, 2West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People&rsquo;s Republic of China; 3Shenzhen Second People&rsquo;s Hospital, Shenzhen, People&rsquo;s Republic of ChinaAbstract: We aimed to evaluate whether the enhancement of the liver accumulation and anti-inflammatory activity of dexamethasone acetate (DXMA) could be achieved by incorporating it into nanostructured lipid carrier (NLCs). DXMA-NLCs were prepared using a film dispersion-ultrasonication method and characterized in terms of particle size, PDI, zeta potential, differential scanning calorimetry, drug loading capacity, encapsulation efficiency, and in vitro release. The biodistribution and pharmacokinetics of DXMA-NLCs in mice were significantly different from those of the DXMA solution (DXMA-sol). The peak concentration of DXMA-NLCs was obtained half an hour after intravenous administration. More than 55.62% of the total administrated dose was present in the liver. An increase of 2.57 fold in the area under the curve was achieved when compared with that of DXMA-sol. DXMA-NLCs exhibited a significant anti-inflammatory and hepatoprotective effect on carrageenan-induced rats and carbon tetrachloride-induced mice compared with DXMA-sol. However, the effect was not in proportion to the dosage. The intermediate and low dosages presented better effects than DXMA-sol. All results indicate that NLCs, as a novel carrier for DXMA, has potential for the treatment of liver diseases, increasing the cure efficiency and decreasing the side effects on other tissues.Keywords: dexamethasone acetate, nanostructured lipid carrier, liver targeting Min-ting WangYun JinYun-xia Yanget alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 487-497 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Min-ting Wang Yun Jin Yun-xia Yang et al In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
description	Min-ting Wang1, Yun Jin1, Yun-xia Yang2, Chun-yan Zhao1, Hong-Yun Yang1, Xue-fan Xu1, Xuan Qin1, Zhao-dan Wang2, Zhi-Rong Zhang1, Yan-lin Jian3, Yuan Huang11Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, 2West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People&rsquo;s Republic of China; 3Shenzhen Second People&rsquo;s Hospital, Shenzhen, People&rsquo;s Republic of ChinaAbstract: We aimed to evaluate whether the enhancement of the liver accumulation and anti-inflammatory activity of dexamethasone acetate (DXMA) could be achieved by incorporating it into nanostructured lipid carrier (NLCs). DXMA-NLCs were prepared using a film dispersion-ultrasonication method and characterized in terms of particle size, PDI, zeta potential, differential scanning calorimetry, drug loading capacity, encapsulation efficiency, and in vitro release. The biodistribution and pharmacokinetics of DXMA-NLCs in mice were significantly different from those of the DXMA solution (DXMA-sol). The peak concentration of DXMA-NLCs was obtained half an hour after intravenous administration. More than 55.62% of the total administrated dose was present in the liver. An increase of 2.57 fold in the area under the curve was achieved when compared with that of DXMA-sol. DXMA-NLCs exhibited a significant anti-inflammatory and hepatoprotective effect on carrageenan-induced rats and carbon tetrachloride-induced mice compared with DXMA-sol. However, the effect was not in proportion to the dosage. The intermediate and low dosages presented better effects than DXMA-sol. All results indicate that NLCs, as a novel carrier for DXMA, has potential for the treatment of liver diseases, increasing the cure efficiency and decreasing the side effects on other tissues.Keywords: dexamethasone acetate, nanostructured lipid carrier, liver targeting
format	article
author	Min-ting Wang Yun Jin Yun-xia Yang et al
author_facet	Min-ting Wang Yun Jin Yun-xia Yang et al
author_sort	Min-ting Wang
title	In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
title_short	In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
title_full	In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
title_fullStr	In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
title_full_unstemmed	In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
title_sort	in vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/55fa116eb350455b93821eaa75d79583
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In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system

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