mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.
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Nature Portfolio
2017
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oai:doaj.org-article:55fa5c77ea474673980a024897c7214c2021-12-02T17:06:20ZmTOR intersects antibody-inducing signals from TACI in marginal zone B cells10.1038/s41467-017-01602-42041-1723https://doaj.org/article/55fa5c77ea474673980a024897c7214c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01602-4https://doaj.org/toc/2041-1723Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.Jordi SintesMaurizio GentileShuling ZhangYolanda Garcia-CarmonaGiuliana MagriLinda CassisDaniel Segura-GarzónAlessandra CiociolaEmilie K. GrassetSabrina BasconesLaura ComermaMarc PybusDavid LligéIrene PugaCindy GutzeitBing HeWendy DuBoisMarta CrespoJulio PascualAnna MensaJuan Ignacio ArósteguiManel JuanJordi YagüeSergi SerranoJosep LloretaEric MeffreMichael HahneCharlotte Cunningham-RundlesBeverly A. MockAndrea CeruttiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jordi Sintes Maurizio Gentile Shuling Zhang Yolanda Garcia-Carmona Giuliana Magri Linda Cassis Daniel Segura-Garzón Alessandra Ciociola Emilie K. Grasset Sabrina Bascones Laura Comerma Marc Pybus David Lligé Irene Puga Cindy Gutzeit Bing He Wendy DuBois Marta Crespo Julio Pascual Anna Mensa Juan Ignacio Aróstegui Manel Juan Jordi Yagüe Sergi Serrano Josep Lloreta Eric Meffre Michael Hahne Charlotte Cunningham-Rundles Beverly A. Mock Andrea Cerutti mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |
| description |
Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation. |
| format |
article |
| author |
Jordi Sintes Maurizio Gentile Shuling Zhang Yolanda Garcia-Carmona Giuliana Magri Linda Cassis Daniel Segura-Garzón Alessandra Ciociola Emilie K. Grasset Sabrina Bascones Laura Comerma Marc Pybus David Lligé Irene Puga Cindy Gutzeit Bing He Wendy DuBois Marta Crespo Julio Pascual Anna Mensa Juan Ignacio Aróstegui Manel Juan Jordi Yagüe Sergi Serrano Josep Lloreta Eric Meffre Michael Hahne Charlotte Cunningham-Rundles Beverly A. Mock Andrea Cerutti |
| author_facet |
Jordi Sintes Maurizio Gentile Shuling Zhang Yolanda Garcia-Carmona Giuliana Magri Linda Cassis Daniel Segura-Garzón Alessandra Ciociola Emilie K. Grasset Sabrina Bascones Laura Comerma Marc Pybus David Lligé Irene Puga Cindy Gutzeit Bing He Wendy DuBois Marta Crespo Julio Pascual Anna Mensa Juan Ignacio Aróstegui Manel Juan Jordi Yagüe Sergi Serrano Josep Lloreta Eric Meffre Michael Hahne Charlotte Cunningham-Rundles Beverly A. Mock Andrea Cerutti |
| author_sort |
Jordi Sintes |
| title |
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |
| title_short |
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |
| title_full |
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |
| title_fullStr |
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |
| title_full_unstemmed |
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells |
| title_sort |
mtor intersects antibody-inducing signals from taci in marginal zone b cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/55fa5c77ea474673980a024897c7214c |
| work_keys_str_mv |
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