Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD

Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD

Ram Lochan Yadav,1 Prakash Kumar Yadav,1 Laxmi Kumari Yadav,2 Kopila Agrawal,3 Santosh Kumar Sah,4 Md Nazrul Islam1 1Department of Physiology, 2Department of Microbiology, Chitwan Medical College, Bharatpur, 3Department of Physiology, BP Koirala Institute of Health Sciences, Dharan, 4Department of B...

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Autores principales: Yadav RL, Yadav PK, Yadav LK, Agrawal K, Sah SK, Islam MN
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Obesity
Heart rate variability (HRV)
Body mass index (BMI)
Waist and hip ratio (WHR)
Cardiac autonomic regulation
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/56007abe984f485085734f6d45bc7c2e
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spelling oai:doaj.org-article:56007abe984f485085734f6d45bc7c2e2021-12-02T00:37:01ZAssociation between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD1178-7007https://doaj.org/article/56007abe984f485085734f6d45bc7c2e2017-02-01T00:00:00Zhttps://www.dovepress.com/association-between-obesity-and-heart-rate-variability-indices-an-intu-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ram Lochan Yadav,1 Prakash Kumar Yadav,1 Laxmi Kumari Yadav,2 Kopila Agrawal,3 Santosh Kumar Sah,4 Md Nazrul Islam1 1Department of Physiology, 2Department of Microbiology, Chitwan Medical College, Bharatpur, 3Department of Physiology, BP Koirala Institute of Health Sciences, Dharan, 4Department of Biochemistry, Janaki Medical College, Janakpur, Nepal Background: Obese people have a higher prevalence of cardiovascular disease, which is supposed to be due to autonomic dysfunction and/or metabolic disorder. The alterations in cardiac autonomic functions bring out the changes in the heart rate variability (HRV) indicators, an assessing tool for cardiac autonomic conditions.Objective: To compare the cardiac autonomic activity between obese and normal weight adults and find out the highest association between the indices of HRV and obesity.Methods: The study was conducted in 30 adult obese persons (body mass index [BMI] >30 kg/m2) and 29 healthy normal weight controls (BMI 18–24 kg/m2). Short-term HRV variables were assessed using standard protocol. Data were compared between groups using Mann–Whitney U test. Obesity indices such as waist circumference, hip circumference, waist–hip ratio (WHR), and BMI were measured and calculated, and they were correlated with HRV indices using Spearman’s correlation analysis.Results: In the obese group, there was a significant increase in the mean heart rate, whereas the HRV parasympathetic indicators were less (eg, root mean square of differences of successive RR intervals [28.75 {16.72–38.35} vs 41.55 {30.6–56.75} ms, p=0.018], number of RR intervals that differ by >50 ms, that is, NN50 [15.5 {2–39} vs 83.5 {32.75–116.25}, p=0.010], etc) and the sympathetic indicator low frequency (LF)/high frequency (HF) ratio (1.2 [0.65–2.20] vs 0.79 [0.5–1.02], p=0.045) was more than that of the normal weight group. Spearman’s correlation between HRV and obesity indices showed significant positive correlation of WHR with LF in normalized unit (r=0.478, p<0.01) and LF/HF ratio (r=0.479, p<0.01), whereas it had significant negative correlation with high frequency power ms2 (r=−0.374, p<0.05) and HF in normalized unit (r=−0.478, p<0.01). There was a nonsignificant correlation of BMI with HRV variables in obese individuals.Conclusion: Increased WHR, by far an indicator of visceral adiposity, was strongly associated with reduced cardiac parasympathetic and increased sympathetic activity in obese individuals defined by BMI. However, BMI itself has a weak relationship with HRV cardiac autonomic markers. Thus, even with a slight increase in WHR in an individual, there could be a greater risk of cardiovascular morbidity and mortality brought about by cardiac autonomic alterations. Keywords: obesity, heart rate variability, HRV, body mass index, BMI, waist–hip ratio, WHR, cardiac autonomic regulationYadav RLYadav PKYadav LKAgrawal KSah SKIslam MNDove Medical PressarticleObesityHeart rate variability (HRV)Body mass index (BMI)Waist and hip ratio (WHR)Cardiac autonomic regulationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 57-64 (2017)
institution DOAJ
collection DOAJ
language EN
topic Obesity
Heart rate variability (HRV)
Body mass index (BMI)
Waist and hip ratio (WHR)
Cardiac autonomic regulation
Specialties of internal medicine
RC581-951
spellingShingle Obesity
Heart rate variability (HRV)
Body mass index (BMI)
Waist and hip ratio (WHR)
Cardiac autonomic regulation
Specialties of internal medicine
RC581-951
Yadav RL
Yadav PK
Yadav LK
Agrawal K
Sah SK
Islam MN
Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD
description Ram Lochan Yadav,1 Prakash Kumar Yadav,1 Laxmi Kumari Yadav,2 Kopila Agrawal,3 Santosh Kumar Sah,4 Md Nazrul Islam1 1Department of Physiology, 2Department of Microbiology, Chitwan Medical College, Bharatpur, 3Department of Physiology, BP Koirala Institute of Health Sciences, Dharan, 4Department of Biochemistry, Janaki Medical College, Janakpur, Nepal Background: Obese people have a higher prevalence of cardiovascular disease, which is supposed to be due to autonomic dysfunction and/or metabolic disorder. The alterations in cardiac autonomic functions bring out the changes in the heart rate variability (HRV) indicators, an assessing tool for cardiac autonomic conditions.Objective: To compare the cardiac autonomic activity between obese and normal weight adults and find out the highest association between the indices of HRV and obesity.Methods: The study was conducted in 30 adult obese persons (body mass index [BMI] >30 kg/m2) and 29 healthy normal weight controls (BMI 18–24 kg/m2). Short-term HRV variables were assessed using standard protocol. Data were compared between groups using Mann–Whitney U test. Obesity indices such as waist circumference, hip circumference, waist–hip ratio (WHR), and BMI were measured and calculated, and they were correlated with HRV indices using Spearman’s correlation analysis.Results: In the obese group, there was a significant increase in the mean heart rate, whereas the HRV parasympathetic indicators were less (eg, root mean square of differences of successive RR intervals [28.75 {16.72–38.35} vs 41.55 {30.6–56.75} ms, p=0.018], number of RR intervals that differ by >50 ms, that is, NN50 [15.5 {2–39} vs 83.5 {32.75–116.25}, p=0.010], etc) and the sympathetic indicator low frequency (LF)/high frequency (HF) ratio (1.2 [0.65–2.20] vs 0.79 [0.5–1.02], p=0.045) was more than that of the normal weight group. Spearman’s correlation between HRV and obesity indices showed significant positive correlation of WHR with LF in normalized unit (r=0.478, p<0.01) and LF/HF ratio (r=0.479, p<0.01), whereas it had significant negative correlation with high frequency power ms2 (r=−0.374, p<0.05) and HF in normalized unit (r=−0.478, p<0.01). There was a nonsignificant correlation of BMI with HRV variables in obese individuals.Conclusion: Increased WHR, by far an indicator of visceral adiposity, was strongly associated with reduced cardiac parasympathetic and increased sympathetic activity in obese individuals defined by BMI. However, BMI itself has a weak relationship with HRV cardiac autonomic markers. Thus, even with a slight increase in WHR in an individual, there could be a greater risk of cardiovascular morbidity and mortality brought about by cardiac autonomic alterations. Keywords: obesity, heart rate variability, HRV, body mass index, BMI, waist–hip ratio, WHR, cardiac autonomic regulation
format article
author Yadav RL
Yadav PK
Yadav LK
Agrawal K
Sah SK
Islam MN
author_facet Yadav RL
Yadav PK
Yadav LK
Agrawal K
Sah SK
Islam MN
author_sort Yadav RL
title Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD
title_short Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD
title_full Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD
title_fullStr Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD
title_full_unstemmed Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD
title_sort association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of cvd
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/56007abe984f485085734f6d45bc7c2e
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