Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis

Alia A El Shahaway,1 Rasha R Abd Elhady,2 Amr Ahmed Abdelrhman,2 Shymaa Yahia11Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, EgyptBackground: Immu...

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Autores principales:	El Shahaway AA, Abd Elhady RR, Abdelrhman AA, Yahia S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	IL-17 preeclampsia inflammatory biomarker hypertension proteinuria Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5600b7de886b4e72b96368f24e966764
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spelling	oai:doaj.org-article:5600b7de886b4e72b96368f24e9667642021-12-02T06:36:53ZRole of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis1178-7031https://doaj.org/article/5600b7de886b4e72b96368f24e9667642019-07-01T00:00:00Zhttps://www.dovepress.com/role-of-maternal-serum-interleukin-17-in-preeclampsia-diagnosis-and-pr-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Alia A El Shahaway,1 Rasha R Abd Elhady,2 Amr Ahmed Abdelrhman,2 Shymaa Yahia11Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, EgyptBackground: Immunological factors play a unique role in the setting of preeclampsia; there is a rising debate about the performance of interleukin 17 (IL-17) as inflammatory mediator in its pathogenesis. The purpose of this paper was to evaluate the significance of IL-17 in the diagnosis and prognosis of preeclampsia and estimate a cutoff value for better prediction.Methods: A prospective case control study, 40 patient were enrolled in the study, two groups were designed: a normotensive (control) group (n=20) and preeclampsia group (n=20). Both groups were compared regarding serum IL-17 level to clarify its significance, then ROC curve analysis was done to establish the best cutoff level to predict preeclampsia, with further assessment of its relation to blood pressure to determine its prognostic value.Results: We noted a statistically significant difference in serum IL-17 (pg/mL) level between the preeclampsia and control group (P<0.05). The best cutoff value of serum IL-17 in preeclampsia was (8.2 pg/mL) with a sensitivity of 100%, specificity 80% and accuracy 89%. There was also significant variation in its concentrations before and after control of blood pressure and a significant positive correlation with systolic blood pressure level (r=0.9).Conclusion: IL-17 is a significant inflammatory biomarker in preeclampsia with useful prognostic power to predict severity of disease.Keywords: IL-17, preeclampsia, inflammatory biomarker, hypertension, proteinuriaEl Shahaway AAAbd Elhady RRAbdelrhman AAYahia SDove Medical PressarticleIL-17preeclampsiainflammatory biomarkerhypertensionproteinuriaPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 12, Pp 175-180 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	IL-17 preeclampsia inflammatory biomarker hypertension proteinuria Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	IL-17 preeclampsia inflammatory biomarker hypertension proteinuria Pathology RB1-214 Therapeutics. Pharmacology RM1-950 El Shahaway AA Abd Elhady RR Abdelrhman AA Yahia S Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
description	Alia A El Shahaway,1 Rasha R Abd Elhady,2 Amr Ahmed Abdelrhman,2 Shymaa Yahia11Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, EgyptBackground: Immunological factors play a unique role in the setting of preeclampsia; there is a rising debate about the performance of interleukin 17 (IL-17) as inflammatory mediator in its pathogenesis. The purpose of this paper was to evaluate the significance of IL-17 in the diagnosis and prognosis of preeclampsia and estimate a cutoff value for better prediction.Methods: A prospective case control study, 40 patient were enrolled in the study, two groups were designed: a normotensive (control) group (n=20) and preeclampsia group (n=20). Both groups were compared regarding serum IL-17 level to clarify its significance, then ROC curve analysis was done to establish the best cutoff level to predict preeclampsia, with further assessment of its relation to blood pressure to determine its prognostic value.Results: We noted a statistically significant difference in serum IL-17 (pg/mL) level between the preeclampsia and control group (P<0.05). The best cutoff value of serum IL-17 in preeclampsia was (8.2 pg/mL) with a sensitivity of 100%, specificity 80% and accuracy 89%. There was also significant variation in its concentrations before and after control of blood pressure and a significant positive correlation with systolic blood pressure level (r=0.9).Conclusion: IL-17 is a significant inflammatory biomarker in preeclampsia with useful prognostic power to predict severity of disease.Keywords: IL-17, preeclampsia, inflammatory biomarker, hypertension, proteinuria
format	article
author	El Shahaway AA Abd Elhady RR Abdelrhman AA Yahia S
author_facet	El Shahaway AA Abd Elhady RR Abdelrhman AA Yahia S
author_sort	El Shahaway AA
title	Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
title_short	Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
title_full	Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
title_fullStr	Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
title_full_unstemmed	Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
title_sort	role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5600b7de886b4e72b96368f24e966764
work_keys_str_mv	AT elshahawayaa roleofmaternalseruminterleukin17inpreeclampsiadiagnosisandprognosis AT abdelhadyrr roleofmaternalseruminterleukin17inpreeclampsiadiagnosisandprognosis AT abdelrhmanaa roleofmaternalseruminterleukin17inpreeclampsiadiagnosisandprognosis AT yahias roleofmaternalseruminterleukin17inpreeclampsiadiagnosisandprognosis
_version_	1718399813639208960

Role of maternal serum interleukin 17 in preeclampsia: diagnosis and prognosis

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