Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacological inhibition triggers senescent cell eliminatio...

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Autores principales:	Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, Snir Cohen, Ezra Vadai, Liat Dassa, Elisheva Shahar, Reba Condiotti, Ittai Ben-Porath, Valery Krizhanovsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/560479e5b34747fb9d70b2a5aea7e0c2
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spelling	oai:doaj.org-article:560479e5b34747fb9d70b2a5aea7e0c22021-12-02T15:34:58ZDirected elimination of senescent cells by inhibition of BCL-W and BCL-XL10.1038/ncomms111902041-1723https://doaj.org/article/560479e5b34747fb9d70b2a5aea7e0c22016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11190https://doaj.org/toc/2041-1723The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacological inhibition triggers senescent cell elimination in mice.Reut YosefNoam PilpelRonit Tokarsky-AmielAnat BiranYossi OvadyaSnir CohenEzra VadaiLiat DassaElisheva ShaharReba CondiottiIttai Ben-PorathValery KrizhanovskyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Reut Yosef Noam Pilpel Ronit Tokarsky-Amiel Anat Biran Yossi Ovadya Snir Cohen Ezra Vadai Liat Dassa Elisheva Shahar Reba Condiotti Ittai Ben-Porath Valery Krizhanovsky Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
description	The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacological inhibition triggers senescent cell elimination in mice.
format	article
author	Reut Yosef Noam Pilpel Ronit Tokarsky-Amiel Anat Biran Yossi Ovadya Snir Cohen Ezra Vadai Liat Dassa Elisheva Shahar Reba Condiotti Ittai Ben-Porath Valery Krizhanovsky
author_facet	Reut Yosef Noam Pilpel Ronit Tokarsky-Amiel Anat Biran Yossi Ovadya Snir Cohen Ezra Vadai Liat Dassa Elisheva Shahar Reba Condiotti Ittai Ben-Porath Valery Krizhanovsky
author_sort	Reut Yosef
title	Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
title_short	Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
title_full	Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
title_fullStr	Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
title_full_unstemmed	Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
title_sort	directed elimination of senescent cells by inhibition of bcl-w and bcl-xl
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/560479e5b34747fb9d70b2a5aea7e0c2
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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

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