Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacological inhibition triggers senescent cell eliminatio...

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Autores principales: Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, Snir Cohen, Ezra Vadai, Liat Dassa, Elisheva Shahar, Reba Condiotti, Ittai Ben-Porath, Valery Krizhanovsky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/560479e5b34747fb9d70b2a5aea7e0c2
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