ATP-citrate lyase promotes axonal transport across species

Microtubule tracks are important for the transport of molecules within axons. Here, the authors show that ATAT1, the enzyme responsible for acetylating a-tubulin, receives acetyl groups from ATP citrate lyase whose stability is regulated by Elongator, a protein mutated in the neuronal disease Famili...

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Autores principales:	Aviel Even, Giovanni Morelli, Silvia Turchetto, Michal Shilian, Romain Le Bail, Sophie Laguesse, Nathalie Krusy, Ariel Brisker, Alexander Brandis, Shani Inbar, Alain Chariot, Frédéric Saudou, Paula Dietrich, Ioannis Dragatsis, Bert Brone, Loïc Broix, Jean-Michel Rigo, Miguel Weil, Laurent Nguyen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56060abcde1a4c4f802c73b700424575
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spelling	oai:doaj.org-article:56060abcde1a4c4f802c73b7004245752021-12-02T19:16:20ZATP-citrate lyase promotes axonal transport across species10.1038/s41467-021-25786-y2041-1723https://doaj.org/article/56060abcde1a4c4f802c73b7004245752021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25786-yhttps://doaj.org/toc/2041-1723Microtubule tracks are important for the transport of molecules within axons. Here, the authors show that ATAT1, the enzyme responsible for acetylating a-tubulin, receives acetyl groups from ATP citrate lyase whose stability is regulated by Elongator, a protein mutated in the neuronal disease Familial dysautonomia.Aviel EvenGiovanni MorelliSilvia TurchettoMichal ShilianRomain Le BailSophie LaguesseNathalie KrusyAriel BriskerAlexander BrandisShani InbarAlain ChariotFrédéric SaudouPaula DietrichIoannis DragatsisBert BroneLoïc BroixJean-Michel RigoMiguel WeilLaurent NguyenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aviel Even Giovanni Morelli Silvia Turchetto Michal Shilian Romain Le Bail Sophie Laguesse Nathalie Krusy Ariel Brisker Alexander Brandis Shani Inbar Alain Chariot Frédéric Saudou Paula Dietrich Ioannis Dragatsis Bert Brone Loïc Broix Jean-Michel Rigo Miguel Weil Laurent Nguyen ATP-citrate lyase promotes axonal transport across species
description	Microtubule tracks are important for the transport of molecules within axons. Here, the authors show that ATAT1, the enzyme responsible for acetylating a-tubulin, receives acetyl groups from ATP citrate lyase whose stability is regulated by Elongator, a protein mutated in the neuronal disease Familial dysautonomia.
format	article
author	Aviel Even Giovanni Morelli Silvia Turchetto Michal Shilian Romain Le Bail Sophie Laguesse Nathalie Krusy Ariel Brisker Alexander Brandis Shani Inbar Alain Chariot Frédéric Saudou Paula Dietrich Ioannis Dragatsis Bert Brone Loïc Broix Jean-Michel Rigo Miguel Weil Laurent Nguyen
author_facet	Aviel Even Giovanni Morelli Silvia Turchetto Michal Shilian Romain Le Bail Sophie Laguesse Nathalie Krusy Ariel Brisker Alexander Brandis Shani Inbar Alain Chariot Frédéric Saudou Paula Dietrich Ioannis Dragatsis Bert Brone Loïc Broix Jean-Michel Rigo Miguel Weil Laurent Nguyen
author_sort	Aviel Even
title	ATP-citrate lyase promotes axonal transport across species
title_short	ATP-citrate lyase promotes axonal transport across species
title_full	ATP-citrate lyase promotes axonal transport across species
title_fullStr	ATP-citrate lyase promotes axonal transport across species
title_full_unstemmed	ATP-citrate lyase promotes axonal transport across species
title_sort	atp-citrate lyase promotes axonal transport across species
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56060abcde1a4c4f802c73b700424575
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ATP-citrate lyase promotes axonal transport across species

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