Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products

Ying-Fei Yang, Wei-Ming Wang, Chi-Yun Chen, Tien-Hsuan Lu, Chung-Min Liao Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617, Republic of China Background: No systematic investigations have been conducted to assess the lung burden imposed by the ch...

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Autores principales:	Yang YF, Wang WM, Chen CY, Lu TH, Liao CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	silver nanoparticles exposure risk lung disease nanotoxicity modeling Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5606ad4e577543268b64933d2f3c4f4a
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spelling	oai:doaj.org-article:5606ad4e577543268b64933d2f3c4f4a2021-12-02T05:24:04ZAssessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products1178-2013https://doaj.org/article/5606ad4e577543268b64933d2f3c4f4a2019-03-01T00:00:00Zhttps://www.dovepress.com/assessing-human-exposure-risk-and-lung-disease-burden-posed-by-airborn-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying-Fei Yang, Wei-Ming Wang, Chi-Yun Chen, Tien-Hsuan Lu, Chung-Min Liao Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617, Republic of China Background: No systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products.Objective: The objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for the estimation of health risks associated with the long-term inhalation of AgNP-containing spray products.Materials and methods: A compartmentalized physiologically based alveolar deposition (PBAD) model was used to estimate AgNP lung burden. Dose–response relationships were established using nanotoxicity data sets obtained from rats (as a model organism). Weibull model-based thresholds of AgNP lung burden based on neutrophil-elevated inflammation biomarkers were estimated from Hill-based exposure–response relationships. Finally, the risks of lung disease posed by various AgNP-containing spray products were assessed.Results: Conservative thresholds for the prevention of pulmonary disease were estimated as follows (mean ± SE): 34 nm AgNPs (0.32±0.22 mg) and 60 nm AgNPs (1.08±0.64 mg). Our results indicate that the risk probability was ~0.5 that the hazard quotient (HQ) estimates of deodorant with a count median diameter (CMD) &tilde;30 nm exceeded 1. The primary risk posed by AgNPs is transferred from the interstitial region to lymph nodes. Under the condition of 50% risk probability, the 97.5 percentile of HQ for the spray products were as follows: CMD &tilde;30 nm (~3.4) and CMD &tilde;60 nm (~1.1).Conclusion: Our application of the proposed risk assessment scheme to the results obtained in an in vivo animal model proved highly effective in elucidating the relationship between the characteristics of metallic NP-containing spray products and their corresponding toxicity. The integration of the proposed PBAD model with a risk assessment framework enables the rapid assessment of risk posed by spray products containing metallic NPs over various time scales. Keywords: silver nanoparticles, spray product, risk assessment, lung burdens, nanotoxicity  Yang YFWang WMChen CYLu THLiao CMDove Medical Pressarticlesilver nanoparticlesexposurerisklung diseasenanotoxicitymodelingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1687-1703 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	silver nanoparticles exposure risk lung disease nanotoxicity modeling Medicine (General) R5-920
spellingShingle	silver nanoparticles exposure risk lung disease nanotoxicity modeling Medicine (General) R5-920 Yang YF Wang WM Chen CY Lu TH Liao CM Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
description	Ying-Fei Yang, Wei-Ming Wang, Chi-Yun Chen, Tien-Hsuan Lu, Chung-Min Liao Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617, Republic of China Background: No systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products.Objective: The objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for the estimation of health risks associated with the long-term inhalation of AgNP-containing spray products.Materials and methods: A compartmentalized physiologically based alveolar deposition (PBAD) model was used to estimate AgNP lung burden. Dose–response relationships were established using nanotoxicity data sets obtained from rats (as a model organism). Weibull model-based thresholds of AgNP lung burden based on neutrophil-elevated inflammation biomarkers were estimated from Hill-based exposure–response relationships. Finally, the risks of lung disease posed by various AgNP-containing spray products were assessed.Results: Conservative thresholds for the prevention of pulmonary disease were estimated as follows (mean ± SE): 34 nm AgNPs (0.32±0.22 mg) and 60 nm AgNPs (1.08±0.64 mg). Our results indicate that the risk probability was ~0.5 that the hazard quotient (HQ) estimates of deodorant with a count median diameter (CMD) &tilde;30 nm exceeded 1. The primary risk posed by AgNPs is transferred from the interstitial region to lymph nodes. Under the condition of 50% risk probability, the 97.5 percentile of HQ for the spray products were as follows: CMD &tilde;30 nm (~3.4) and CMD &tilde;60 nm (~1.1).Conclusion: Our application of the proposed risk assessment scheme to the results obtained in an in vivo animal model proved highly effective in elucidating the relationship between the characteristics of metallic NP-containing spray products and their corresponding toxicity. The integration of the proposed PBAD model with a risk assessment framework enables the rapid assessment of risk posed by spray products containing metallic NPs over various time scales. Keywords: silver nanoparticles, spray product, risk assessment, lung burdens, nanotoxicity
format	article
author	Yang YF Wang WM Chen CY Lu TH Liao CM
author_facet	Yang YF Wang WM Chen CY Lu TH Liao CM
author_sort	Yang YF
title	Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
title_short	Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
title_full	Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
title_fullStr	Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
title_full_unstemmed	Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
title_sort	assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5606ad4e577543268b64933d2f3c4f4a
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Assessing human exposure risk and lung disease burden posed by airborne silver nanoparticles emitted by consumer spray products

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