Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease

Abstract Background Southeast Asia represents 10% of the global population, yet little is known about regional clinical characteristics of dementia and risk factors for dementia progression. This study aims to describe the clinico-demographic profiles of dementia in Southeast Asia and investigate th...

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Autores principales:	Ashwati Vipin, Vaynii Satish, Seyed Ehsan Saffari, Wilbur Koh, Levinia Lim, Eveline Silva, Mei Mei Nyu, Tanya-Marie Choong, Esther Chua, Linda Lim, Adeline Su Lyn Ng, Hui Jin Chiew, Kok Pin Ng, Nagaendran Kandiah
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Longitudinal Clinical Alzheimer’s disease Cognition Education Cerebrovascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/56096e9c3197411e80b7d5c14ba60513
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spelling	oai:doaj.org-article:56096e9c3197411e80b7d5c14ba605132021-12-05T12:24:32ZDementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease10.1186/s13195-021-00936-y1758-9193https://doaj.org/article/56096e9c3197411e80b7d5c14ba605132021-11-01T00:00:00Zhttps://doi.org/10.1186/s13195-021-00936-yhttps://doaj.org/toc/1758-9193Abstract Background Southeast Asia represents 10% of the global population, yet little is known about regional clinical characteristics of dementia and risk factors for dementia progression. This study aims to describe the clinico-demographic profiles of dementia in Southeast Asia and investigate the association of onset-type, education, and cerebrovascular disease (CVD) on dementia progression in a real-world clinic setting. Methods In this longitudinal study, participants were consecutive series of 1606 patients with dementia from 2010 to 2019 from a tertiary memory clinic from Singapore. The frequency of dementia subtypes stratified into young-onset (YOD; <65 years age-at-onset) and late-onset dementia (LOD; ≥65 years age-at-onset) was studied. Association of onset-type (YOD or LOD), years of lifespan education, and CVD on the trajectory of cognition was evaluated using linear mixed models. The time to significant cognitive decline was investigated using Kaplan-Meier analysis. Results Dementia of the Alzheimer’s type (DAT) was the most common diagnosis (59.8%), followed by vascular dementia (14.9%) and frontotemporal dementia (11.1%). YOD patients accounted for 28.5% of all dementia patients. Patients with higher lifespan education had a steeper decline in global cognition (p<0.001), with this finding being more pronounced in YOD (p=0.0006). Older patients with a moderate-to-severe burden of CVD demonstrated a trend for a faster decline in global cognition compared to those with a mild burden. Conclusions There is a high frequency of YOD with DAT being most common in our Southeast Asian memory clinic cohort. YOD patients with higher lifespan education and LOD patients with moderate-to-severe CVD experience a steep decline in cognition.Ashwati VipinVaynii SatishSeyed Ehsan SaffariWilbur KohLevinia LimEveline SilvaMei Mei NyuTanya-Marie ChoongEsther ChuaLinda LimAdeline Su Lyn NgHui Jin ChiewKok Pin NgNagaendran KandiahBMCarticleLongitudinalClinicalAlzheimer’s diseaseCognitionEducationCerebrovascular diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAlzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Longitudinal Clinical Alzheimer’s disease Cognition Education Cerebrovascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Longitudinal Clinical Alzheimer’s disease Cognition Education Cerebrovascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ashwati Vipin Vaynii Satish Seyed Ehsan Saffari Wilbur Koh Levinia Lim Eveline Silva Mei Mei Nyu Tanya-Marie Choong Esther Chua Linda Lim Adeline Su Lyn Ng Hui Jin Chiew Kok Pin Ng Nagaendran Kandiah Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
description	Abstract Background Southeast Asia represents 10% of the global population, yet little is known about regional clinical characteristics of dementia and risk factors for dementia progression. This study aims to describe the clinico-demographic profiles of dementia in Southeast Asia and investigate the association of onset-type, education, and cerebrovascular disease (CVD) on dementia progression in a real-world clinic setting. Methods In this longitudinal study, participants were consecutive series of 1606 patients with dementia from 2010 to 2019 from a tertiary memory clinic from Singapore. The frequency of dementia subtypes stratified into young-onset (YOD; <65 years age-at-onset) and late-onset dementia (LOD; ≥65 years age-at-onset) was studied. Association of onset-type (YOD or LOD), years of lifespan education, and CVD on the trajectory of cognition was evaluated using linear mixed models. The time to significant cognitive decline was investigated using Kaplan-Meier analysis. Results Dementia of the Alzheimer’s type (DAT) was the most common diagnosis (59.8%), followed by vascular dementia (14.9%) and frontotemporal dementia (11.1%). YOD patients accounted for 28.5% of all dementia patients. Patients with higher lifespan education had a steeper decline in global cognition (p<0.001), with this finding being more pronounced in YOD (p=0.0006). Older patients with a moderate-to-severe burden of CVD demonstrated a trend for a faster decline in global cognition compared to those with a mild burden. Conclusions There is a high frequency of YOD with DAT being most common in our Southeast Asian memory clinic cohort. YOD patients with higher lifespan education and LOD patients with moderate-to-severe CVD experience a steep decline in cognition.
format	article
author	Ashwati Vipin Vaynii Satish Seyed Ehsan Saffari Wilbur Koh Levinia Lim Eveline Silva Mei Mei Nyu Tanya-Marie Choong Esther Chua Linda Lim Adeline Su Lyn Ng Hui Jin Chiew Kok Pin Ng Nagaendran Kandiah
author_facet	Ashwati Vipin Vaynii Satish Seyed Ehsan Saffari Wilbur Koh Levinia Lim Eveline Silva Mei Mei Nyu Tanya-Marie Choong Esther Chua Linda Lim Adeline Su Lyn Ng Hui Jin Chiew Kok Pin Ng Nagaendran Kandiah
author_sort	Ashwati Vipin
title	Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
title_short	Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
title_full	Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
title_fullStr	Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
title_full_unstemmed	Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease
title_sort	dementia in southeast asia: influence of onset-type, education, and cerebrovascular disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/56096e9c3197411e80b7d5c14ba60513
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Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease

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