Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Outer membrane vesicles (OMVs), non-replicative particles secreted by Gram-negative bacteria, are known for their immunostimulatory and adjuvant properties. Here, by employing a Plug-and-Display technology, the authors engineer OMVs to display tumor antigens on the surface, a platform that promotes...

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Autores principales: Keman Cheng, Ruifang Zhao, Yao Li, Yingqiu Qi, Yazhou Wang, Yinlong Zhang, Hao Qin, Yuting Qin, Long Chen, Chen Li, Jie Liang, Yujing Li, Jiaqi Xu, Xuexiang Han, Gregory J. Anderson, Jian Shi, Lei Ren, Xiao Zhao, Guangjun Nie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/56098fde2e874357a1a54ea92a902505
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spelling oai:doaj.org-article:56098fde2e874357a1a54ea92a9025052021-12-02T18:15:29ZBioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology10.1038/s41467-021-22308-82041-1723https://doaj.org/article/56098fde2e874357a1a54ea92a9025052021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22308-8https://doaj.org/toc/2041-1723Outer membrane vesicles (OMVs), non-replicative particles secreted by Gram-negative bacteria, are known for their immunostimulatory and adjuvant properties. Here, by employing a Plug-and-Display technology, the authors engineer OMVs to display tumor antigens on the surface, a platform that promotes anti-tumor immune responses in preclinical cancer models.Keman ChengRuifang ZhaoYao LiYingqiu QiYazhou WangYinlong ZhangHao QinYuting QinLong ChenChen LiJie LiangYujing LiJiaqi XuXuexiang HanGregory J. AndersonJian ShiLei RenXiao ZhaoGuangjun NieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Keman Cheng
Ruifang Zhao
Yao Li
Yingqiu Qi
Yazhou Wang
Yinlong Zhang
Hao Qin
Yuting Qin
Long Chen
Chen Li
Jie Liang
Yujing Li
Jiaqi Xu
Xuexiang Han
Gregory J. Anderson
Jian Shi
Lei Ren
Xiao Zhao
Guangjun Nie
Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
description Outer membrane vesicles (OMVs), non-replicative particles secreted by Gram-negative bacteria, are known for their immunostimulatory and adjuvant properties. Here, by employing a Plug-and-Display technology, the authors engineer OMVs to display tumor antigens on the surface, a platform that promotes anti-tumor immune responses in preclinical cancer models.
format article
author Keman Cheng
Ruifang Zhao
Yao Li
Yingqiu Qi
Yazhou Wang
Yinlong Zhang
Hao Qin
Yuting Qin
Long Chen
Chen Li
Jie Liang
Yujing Li
Jiaqi Xu
Xuexiang Han
Gregory J. Anderson
Jian Shi
Lei Ren
Xiao Zhao
Guangjun Nie
author_facet Keman Cheng
Ruifang Zhao
Yao Li
Yingqiu Qi
Yazhou Wang
Yinlong Zhang
Hao Qin
Yuting Qin
Long Chen
Chen Li
Jie Liang
Yujing Li
Jiaqi Xu
Xuexiang Han
Gregory J. Anderson
Jian Shi
Lei Ren
Xiao Zhao
Guangjun Nie
author_sort Keman Cheng
title Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
title_short Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
title_full Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
title_fullStr Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
title_full_unstemmed Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology
title_sort bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via plug-and-display technology
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/56098fde2e874357a1a54ea92a902505
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