DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of targe...

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Autores principales:	Xin-Xuan Lin, Ilke Sen, Georges E. Janssens, Xin Zhou, Bryan R. Fonslow, Daniel Edgar, Nicholas Stroustrup, Peter Swoboda, John R. Yates, Gary Ruvkun, Christian G. Riedel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/560c3b80b1d74b0b81296e799f7bb7fb
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spelling	oai:doaj.org-article:560c3b80b1d74b0b81296e799f7bb7fb2021-12-02T14:41:17ZDAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity10.1038/s41467-018-06624-02041-1723https://doaj.org/article/560c3b80b1d74b0b81296e799f7bb7fb2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06624-0https://doaj.org/toc/2041-1723The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of target genes in response to certain stress stimuli.Xin-Xuan LinIlke SenGeorges E. JanssensXin ZhouBryan R. FonslowDaniel EdgarNicholas StroustrupPeter SwobodaJohn R. YatesGary RuvkunChristian G. RiedelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin-Xuan Lin Ilke Sen Georges E. Janssens Xin Zhou Bryan R. Fonslow Daniel Edgar Nicholas Stroustrup Peter Swoboda John R. Yates Gary Ruvkun Christian G. Riedel DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
description	The transcription factor DAF-16/FOXO is a downstream effector of insulin/insulin-like growth factor signaling and plays an important role in stress resistance and longevity. Here, the authors show that DAF-16/FOXO can form a complex with HLH-30/TFEB to synergistically regulate transcription of target genes in response to certain stress stimuli.
format	article
author	Xin-Xuan Lin Ilke Sen Georges E. Janssens Xin Zhou Bryan R. Fonslow Daniel Edgar Nicholas Stroustrup Peter Swoboda John R. Yates Gary Ruvkun Christian G. Riedel
author_facet	Xin-Xuan Lin Ilke Sen Georges E. Janssens Xin Zhou Bryan R. Fonslow Daniel Edgar Nicholas Stroustrup Peter Swoboda John R. Yates Gary Ruvkun Christian G. Riedel
author_sort	Xin-Xuan Lin
title	DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
title_short	DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
title_full	DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
title_fullStr	DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
title_full_unstemmed	DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
title_sort	daf-16/foxo and hlh-30/tfeb function as combinatorial transcription factors to promote stress resistance and longevity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/560c3b80b1d74b0b81296e799f7bb7fb
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DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

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