Oxidative stress, aging, and diseases

Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II&rdq...

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Autores principales:	Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	elderly reactive oxygen species reactive nitrogen species antioxidants Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/560da0c26eb3428eb392fab5faf1c8e6
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spelling	oai:doaj.org-article:560da0c26eb3428eb392fab5faf1c8e62021-12-02T09:23:47ZOxidative stress, aging, and diseases1178-1998https://doaj.org/article/560da0c26eb3428eb392fab5faf1c8e62018-04-01T00:00:00Zhttps://www.dovepress.com/oxidative-stress-aging-and-diseases-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of this paper is to provide a review of literature on this complex topic of ever increasing interest. Keywords: elderly, reactive oxygen species, reactive nitrogen species, antioxidantsLiguori IRusso GCurcio FBulli GAran LDella-Morte DGargiulo GTesta GCacciatore FBonaduce DAbete PDove Medical Pressarticleelderlyreactive oxygen speciesreactive nitrogen speciesantioxidantsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 757-772 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	elderly reactive oxygen species reactive nitrogen species antioxidants Geriatrics RC952-954.6
spellingShingle	elderly reactive oxygen species reactive nitrogen species antioxidants Geriatrics RC952-954.6 Liguori I Russo G Curcio F Bulli G Aran L Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P Oxidative stress, aging, and diseases
description	Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of this paper is to provide a review of literature on this complex topic of ever increasing interest. Keywords: elderly, reactive oxygen species, reactive nitrogen species, antioxidants
format	article
author	Liguori I Russo G Curcio F Bulli G Aran L Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P
author_facet	Liguori I Russo G Curcio F Bulli G Aran L Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P
author_sort	Liguori I
title	Oxidative stress, aging, and diseases
title_short	Oxidative stress, aging, and diseases
title_full	Oxidative stress, aging, and diseases
title_fullStr	Oxidative stress, aging, and diseases
title_full_unstemmed	Oxidative stress, aging, and diseases
title_sort	oxidative stress, aging, and diseases
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/560da0c26eb3428eb392fab5faf1c8e6
work_keys_str_mv	AT liguorii oxidativestressaginganddiseases AT russog oxidativestressaginganddiseases AT curciof oxidativestressaginganddiseases AT bullig oxidativestressaginganddiseases AT aranl oxidativestressaginganddiseases AT dellamorted oxidativestressaginganddiseases AT gargiulog oxidativestressaginganddiseases AT testag oxidativestressaginganddiseases AT cacciatoref oxidativestressaginganddiseases AT bonaduced oxidativestressaginganddiseases AT abetep oxidativestressaginganddiseases
_version_	1718398121939042304

Oxidative stress, aging, and diseases

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