Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis
Abstract Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quanti...
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Nature Portfolio
2021
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oai:doaj.org-article:5612f91bb5fa49babedc218abf921df82021-12-02T16:14:09ZProteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis10.1038/s41598-021-94256-82045-2322https://doaj.org/article/5612f91bb5fa49babedc218abf921df82021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94256-8https://doaj.org/toc/2045-2322Abstract Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quantification proteomics and untargeted metabolomics were used to screen disease-related signaling pathways through clustering and enrichment analysis of the differential expression of proteins and metabolites. The main imaging features were lesions located in the bilateral lower lobes and involvement in five lobes. The closed association pathways were FcγR-mediated phagocytosis, PPAR signaling, TRP-inflammatory pathways, and the urea cycle. Our results provide evidence for the detection of serum biomarkers and targeted therapy in patients with Covid-19.Jianrong YangChunxia ChenWan ChenLuying HuangZhao FuKun YeLiwen LvZhihuang NongXing ZhouWensheng LuMei ZhongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jianrong Yang Chunxia Chen Wan Chen Luying Huang Zhao Fu Kun Ye Liwen Lv Zhihuang Nong Xing Zhou Wensheng Lu Mei Zhong Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| description |
Abstract Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quantification proteomics and untargeted metabolomics were used to screen disease-related signaling pathways through clustering and enrichment analysis of the differential expression of proteins and metabolites. The main imaging features were lesions located in the bilateral lower lobes and involvement in five lobes. The closed association pathways were FcγR-mediated phagocytosis, PPAR signaling, TRP-inflammatory pathways, and the urea cycle. Our results provide evidence for the detection of serum biomarkers and targeted therapy in patients with Covid-19. |
| format |
article |
| author |
Jianrong Yang Chunxia Chen Wan Chen Luying Huang Zhao Fu Kun Ye Liwen Lv Zhihuang Nong Xing Zhou Wensheng Lu Mei Zhong |
| author_facet |
Jianrong Yang Chunxia Chen Wan Chen Luying Huang Zhao Fu Kun Ye Liwen Lv Zhihuang Nong Xing Zhou Wensheng Lu Mei Zhong |
| author_sort |
Jianrong Yang |
| title |
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| title_short |
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| title_full |
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| title_fullStr |
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| title_full_unstemmed |
Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis |
| title_sort |
proteomics and metabonomics analyses of covid-19 complications in patients with pulmonary fibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5612f91bb5fa49babedc218abf921df8 |
| work_keys_str_mv |
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| _version_ |
1718384350050910208 |